Functions and mechanisms of UC-MSC-derived exosomal miR-486-5p in pulmonary fibrosis

Functions and mechanisms of UC-MSC-derived exosomal miR-486-5p in pulmonary fibrosis

BackgroundCurrently, nintedanib and pirfenidone are the two primary pharmacological agents used to treat pulmonary fibrosis (PF). However, neither of these medications effectively halts the progression of PF or preserves lung function. As a result, lung transplantation remains the sole viable treatm...

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Bibliographic Details
Main Authors: Xue-feng Shi, Ya-jun Tuo, Zhen-yun Liao, Jie Duo, Hao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
pulmonary fibrosis
stem cells
exosomes
miR-486-5p
fibroblast differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1542008/full
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