Sex differences in the association between repetitive negative thinking and neurofilament light
Abstract Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer’s disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are assoc...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-11-01
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| Series: | npj Mental Health Research |
| Online Access: | https://doi.org/10.1038/s44184-024-00093-8 |
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| author | Yolanda Lau Amit Bansal Cassandre Palix Harriet Demnitz-King Miranka Wirth Olga Klimecki Gael Chetelat Géraldine Poisnel Natalie L. Marchant The Medit-Ageing Research Group |
| author_facet | Yolanda Lau Amit Bansal Cassandre Palix Harriet Demnitz-King Miranka Wirth Olga Klimecki Gael Chetelat Géraldine Poisnel Natalie L. Marchant The Medit-Ageing Research Group |
| author_sort | Yolanda Lau |
| collection | DOAJ |
| description | Abstract Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer’s disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women. |
| format | Article |
| id | doaj-art-5f865d7d35054fafa9c8b50376e3ad93 |
| institution | Kabale University |
| issn | 2731-4251 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Mental Health Research |
| spelling | doaj-art-5f865d7d35054fafa9c8b50376e3ad932025-01-19T12:43:39ZengNature Portfolionpj Mental Health Research2731-42512024-11-01311910.1038/s44184-024-00093-8Sex differences in the association between repetitive negative thinking and neurofilament lightYolanda Lau0Amit Bansal1Cassandre Palix2Harriet Demnitz-King3Miranka Wirth4Olga Klimecki5Gael Chetelat6Géraldine Poisnel7Natalie L. Marchant8The Medit-Ageing Research GroupDivision of Psychiatry, Faculty of Brain Sciences, University College LondonDivision of Psychiatry, Faculty of Brain Sciences, University College LondonNormandy University, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders” NeuroPresage Team, CyceronDivision of Psychiatry, Faculty of Brain Sciences, University College LondonGerman Center for Neurodegenerative Diseases (DZNE)Developmental Psychology, Friedrich Schiller University JenaNormandy University, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders” NeuroPresage Team, CyceronNormandy University, UNICAEN, INSERM, U1237, PhIND “Physiopathology and Imaging of Neurological Disorders” NeuroPresage Team, CyceronDivision of Psychiatry, Faculty of Brain Sciences, University College LondonAbstract Emerging evidence suggests that repetitive negative thinking (RNT; i.e., worry and ruminative brooding) is associated with biomarkers of Alzheimer’s disease. Given that women have a greater risk of many neurodegenerative diseases, this study investigated whether worry and brooding are associated with general neurodegeneration and whether associations differ by sex. Exploratory analyses examined whether allostatic load, a marker of chronic stress, mediates any observed relationships. Baseline data from 134 cognitively healthy older adults in the Age-Well clinical trial were utilised. Worry and brooding were assessed using questionnaires. Plasma neurofilament light chain (NfL), a biomarker of neurodegeneration, was quantified using a Meso Scale Discovery assay. We found a positive interaction between brooding and sex on NfL, with higher brooding associated with greater NfL levels in women. No associations were observed between worry/ruminative brooding and allostatic load. These results offer preliminary support that RNT is associated with worse brain health, specifically in women.https://doi.org/10.1038/s44184-024-00093-8 |
| spellingShingle | Yolanda Lau Amit Bansal Cassandre Palix Harriet Demnitz-King Miranka Wirth Olga Klimecki Gael Chetelat Géraldine Poisnel Natalie L. Marchant The Medit-Ageing Research Group Sex differences in the association between repetitive negative thinking and neurofilament light npj Mental Health Research |
| title | Sex differences in the association between repetitive negative thinking and neurofilament light |
| title_full | Sex differences in the association between repetitive negative thinking and neurofilament light |
| title_fullStr | Sex differences in the association between repetitive negative thinking and neurofilament light |
| title_full_unstemmed | Sex differences in the association between repetitive negative thinking and neurofilament light |
| title_short | Sex differences in the association between repetitive negative thinking and neurofilament light |
| title_sort | sex differences in the association between repetitive negative thinking and neurofilament light |
| url | https://doi.org/10.1038/s44184-024-00093-8 |
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