Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results
Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinica...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/8174340 |
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| author | Edyta Dziadkowiak Agata Sebastian Małgorzata Wieczorek Elżbieta Kusińska Marta Waliszewska-Prosół Piotr Wiland Maria Ejma |
| author_facet | Edyta Dziadkowiak Agata Sebastian Małgorzata Wieczorek Elżbieta Kusińska Marta Waliszewska-Prosół Piotr Wiland Maria Ejma |
| author_sort | Edyta Dziadkowiak |
| collection | DOAJ |
| description | Primary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS damage and normal head computed tomography scan, somatosensory evoked potentials (SEP) were studied. The results were compared to other clinical parameters of the disease, particularly to immunological status. The control group consisted of 20 healthy volunteers. Mean latency of all components of SEP was considerably prolonged in patients compared to the control group. Mean interpeak latency N20-N13 (duration of central conduction TT) did not differ significantly between the groups. However, in the study group, mean amplitude of N20P22 and N13P16 was significantly higher compared to healthy individuals. In patients with pSS, significant differences in SEP parameters depending on the duration of the disease and presence of SSA and SSB antibodies were noted. The authors confirmed CNS involvement often observed in patients with pSS. They also showed dysfunction of the central sensory neuron as a difference in the amplitude of cortical response, which indicates subclinical damage to the CNS. |
| format | Article |
| id | doaj-art-5f779be579694c1c978b9505d95c39d1 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5f779be579694c1c978b9505d95c39d12025-02-03T01:06:41ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/81743408174340Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary ResultsEdyta Dziadkowiak0Agata Sebastian1Małgorzata Wieczorek2Elżbieta Kusińska3Marta Waliszewska-Prosół4Piotr Wiland5Maria Ejma6Department of Neurology, Wroclaw Medical Hospital, Borowska 213, 50-556 Wroclaw, PolandDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Geoinformatics and Cartography, Institute of Geography and Regional Development, University of Wroclaw, Uniwersytecki 1, 50-136 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Rheumatology and Internal Medicine, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandDepartment of Neurology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, PolandPrimary Sjogren’s syndrome (pSS) is a chronic autoimmune disease. The aim of the study was to establish whether in patients with pSS without central nervous system (CNS) involvement, the function of the central portion of the sensory pathway can be challenged. In 33 patients with pSS without clinical features of CNS damage and normal head computed tomography scan, somatosensory evoked potentials (SEP) were studied. The results were compared to other clinical parameters of the disease, particularly to immunological status. The control group consisted of 20 healthy volunteers. Mean latency of all components of SEP was considerably prolonged in patients compared to the control group. Mean interpeak latency N20-N13 (duration of central conduction TT) did not differ significantly between the groups. However, in the study group, mean amplitude of N20P22 and N13P16 was significantly higher compared to healthy individuals. In patients with pSS, significant differences in SEP parameters depending on the duration of the disease and presence of SSA and SSB antibodies were noted. The authors confirmed CNS involvement often observed in patients with pSS. They also showed dysfunction of the central sensory neuron as a difference in the amplitude of cortical response, which indicates subclinical damage to the CNS.http://dx.doi.org/10.1155/2018/8174340 |
| spellingShingle | Edyta Dziadkowiak Agata Sebastian Małgorzata Wieczorek Elżbieta Kusińska Marta Waliszewska-Prosół Piotr Wiland Maria Ejma Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results Journal of Immunology Research |
| title | Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results |
| title_full | Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results |
| title_fullStr | Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results |
| title_full_unstemmed | Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results |
| title_short | Parameters of Somatosensory Evoked Potentials in Patients with Primary Sjӧgren’s Syndrome: Preliminary Results |
| title_sort | parameters of somatosensory evoked potentials in patients with primary sjӧgren s syndrome preliminary results |
| url | http://dx.doi.org/10.1155/2018/8174340 |
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