Nitroglycerin for Management of Retained Placenta: A Multicenter Study
The primary aim was to determine if sequential administration of oxytocin and nitroglycerin is effective for management of retained placenta when performed by obstetricians with no experience of the method. Secondary aims were to examine possible adverse effects of nitroglycerin. One hundred and fiv...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2012/321207 |
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| _version_ | 1832548058384039936 |
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| author | Maria Bullarbo Hans Bokström Håkan Lilja Elisabeth Almström Nina Lassenius Agneta Hansson Erling Ekerhovd |
| author_facet | Maria Bullarbo Hans Bokström Håkan Lilja Elisabeth Almström Nina Lassenius Agneta Hansson Erling Ekerhovd |
| author_sort | Maria Bullarbo |
| collection | DOAJ |
| description | The primary aim was to determine if sequential administration of oxytocin and nitroglycerin is effective for management of retained placenta when performed by obstetricians with no experience of the method. Secondary aims were to examine possible adverse effects of nitroglycerin. One hundred and five women with retained placenta were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin had failed to expel the placenta. At two of the hospitals some of the midwives were familiar with the use of nitroglycerin. The other midwives and all the participating obstetricians had no clinical experience of the method. In the treatment group, detachment of placenta following nitroglycerin occurred in 37.3% of the women compared to 20.4% in the placebo group (P=0.056). In the two hospitals with some experience of the method, placenta was removed in 9 of 19 (47.4%) women in the nitroglycerin group compared to 3 of 17 (15.0%) women in the placebo group. No adverse effects of clinical importance were registered. Although the difference between the two groups did not reach statistical significance, the higher success rate in the two hospitals with some experience could indicate that clinical experience is of importance in order to achieve placental detachment. |
| format | Article |
| id | doaj-art-5f756a8524fe4272a4f6b39d7e7f3117 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-5f756a8524fe4272a4f6b39d7e7f31172025-02-03T06:42:18ZengWileyObstetrics and Gynecology International1687-95891687-95972012-01-01201210.1155/2012/321207321207Nitroglycerin for Management of Retained Placenta: A Multicenter StudyMaria Bullarbo0Hans Bokström1Håkan Lilja2Elisabeth Almström3Nina Lassenius4Agneta Hansson5Erling Ekerhovd6Department of Obstetrics and Gynecology, Södra Älvsborg Hospital, 501 82 Borås, SwedenDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital, 413 45 Gothenburg, SwedenDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital, 413 45 Gothenburg, SwedenDepartment of Obstetrics and Gynecology, NÄL Hospital, 461 85 Trollhättan, SwedenDepartment of Obstetrics and Gynecology, Vrinnevi Hospital, 603 79 Norrköping, SwedenDepartment of Obstetrics and Gynecology, Central Hospital of Karlstad, 651 85 Karlstad, SwedenDepartment of Obstetrics and Gynecology, Sahlgrenska University Hospital, 413 45 Gothenburg, SwedenThe primary aim was to determine if sequential administration of oxytocin and nitroglycerin is effective for management of retained placenta when performed by obstetricians with no experience of the method. Secondary aims were to examine possible adverse effects of nitroglycerin. One hundred and five women with retained placenta were randomly selected to receive either 1 mg nitroglycerin or placebo tablets sublingually if intravenous oxytocin had failed to expel the placenta. At two of the hospitals some of the midwives were familiar with the use of nitroglycerin. The other midwives and all the participating obstetricians had no clinical experience of the method. In the treatment group, detachment of placenta following nitroglycerin occurred in 37.3% of the women compared to 20.4% in the placebo group (P=0.056). In the two hospitals with some experience of the method, placenta was removed in 9 of 19 (47.4%) women in the nitroglycerin group compared to 3 of 17 (15.0%) women in the placebo group. No adverse effects of clinical importance were registered. Although the difference between the two groups did not reach statistical significance, the higher success rate in the two hospitals with some experience could indicate that clinical experience is of importance in order to achieve placental detachment.http://dx.doi.org/10.1155/2012/321207 |
| spellingShingle | Maria Bullarbo Hans Bokström Håkan Lilja Elisabeth Almström Nina Lassenius Agneta Hansson Erling Ekerhovd Nitroglycerin for Management of Retained Placenta: A Multicenter Study Obstetrics and Gynecology International |
| title | Nitroglycerin for Management of Retained Placenta: A Multicenter Study |
| title_full | Nitroglycerin for Management of Retained Placenta: A Multicenter Study |
| title_fullStr | Nitroglycerin for Management of Retained Placenta: A Multicenter Study |
| title_full_unstemmed | Nitroglycerin for Management of Retained Placenta: A Multicenter Study |
| title_short | Nitroglycerin for Management of Retained Placenta: A Multicenter Study |
| title_sort | nitroglycerin for management of retained placenta a multicenter study |
| url | http://dx.doi.org/10.1155/2012/321207 |
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