Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation

Exploration of the mechanism of Lithospermum erythrorhizon oil in treating atopic dermatitis based on network pharmacology and experimental validation of the PI3K-Akt pathway regulation

Objective: This study aimed to explore the molecular mechanisms of Lithospermum erythrorhizon oil in treating atopic dermatitis (AD), with a particular focus on its regulatory effect on the PI3K-Akt signaling pathway. Methods: Utilizing a network pharmacology approach integrated with experimental va...

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Bibliographic Details
Main Authors: Weisheng Hu, Yinlan Wang, Yingjie Zhou, Junbao Shi, Zengyan Li, Xiaoling Jiang, Qinyuan Wu, Changming Zhong, Huilan Weng, Sijie Ouyang, Yuan Jing, Xianxiang Cai, Mingda Ye, Ning Huang
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Heliyon
Subjects:
Atopic dermatitis
Lithospermum erythrorhizon oil
Network pharmacology
Experimental validation
Molecular mechanism
PI3K-Akt signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025000878
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