Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding
Abstract Developing a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromole...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-01-01
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| Series: | Microsystems & Nanoengineering |
| Online Access: | https://doi.org/10.1038/s41378-024-00865-4 |
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| author | Jinsol Choi Chi Yeung Oh Gong Qian Tae Soup Shim Heon-Ho Jeong |
| author_facet | Jinsol Choi Chi Yeung Oh Gong Qian Tae Soup Shim Heon-Ho Jeong |
| author_sort | Jinsol Choi |
| collection | DOAJ |
| description | Abstract Developing a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromolecule-driven flow (MDF) gate and photonic crystal (PhC) coding units, enabling portable and scalable detection and discrimination of various organic chemical, mimicking the olfactory system. The MDF gate is designed for precise flow control of liquid analytes, which depends on intermolecular interactions between the polymer at the MDF gate and the liquid analytes. Subsequently, the PhC coding unit allows for visualizing the result obtained from the MDF gate and generating differential optical patterns. We fabricate an optofluidic PAD by integrating two coding units into a three-dimensional (3D) microfluidic paper within a 3D-printed cartridge. The optofluidic PADs clearly distinguish 11 organic chemicals with digital readout of pattern recognition from colorimetric signals. We believe that our optofluidic coding strategy mimicking the olfactory system opens up a wide range of potential applications in colorimetric monitoring of chemicals observed in environment. |
| format | Article |
| id | doaj-art-5f5a3df6c9d64913afa90afb5af22266 |
| institution | Kabale University |
| issn | 2055-7434 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Microsystems & Nanoengineering |
| spelling | doaj-art-5f5a3df6c9d64913afa90afb5af222662025-01-19T12:27:07ZengNature Publishing GroupMicrosystems & Nanoengineering2055-74342025-01-0111111010.1038/s41378-024-00865-4Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color codingJinsol Choi0Chi Yeung Oh1Gong Qian2Tae Soup Shim3Heon-Ho Jeong4Department of Chemical and Biomolecular Engineering, Chonnam National UniversityDepartment of Energy Systems Research, Ajou UniversityDepartment of Chemical and Biomolecular Engineering, Chonnam National UniversityDepartment of Energy Systems Research, Ajou UniversityDepartment of Chemical and Biomolecular Engineering, Chonnam National UniversityAbstract Developing a portable yet affordable method for the discrimination of chemical substances with good sensitivity and selectivity is essential for on-site visual detection of unknown substances. Herein, we propose an optofluidic paper-based analytical device (PAD) that consists of a macromolecule-driven flow (MDF) gate and photonic crystal (PhC) coding units, enabling portable and scalable detection and discrimination of various organic chemical, mimicking the olfactory system. The MDF gate is designed for precise flow control of liquid analytes, which depends on intermolecular interactions between the polymer at the MDF gate and the liquid analytes. Subsequently, the PhC coding unit allows for visualizing the result obtained from the MDF gate and generating differential optical patterns. We fabricate an optofluidic PAD by integrating two coding units into a three-dimensional (3D) microfluidic paper within a 3D-printed cartridge. The optofluidic PADs clearly distinguish 11 organic chemicals with digital readout of pattern recognition from colorimetric signals. We believe that our optofluidic coding strategy mimicking the olfactory system opens up a wide range of potential applications in colorimetric monitoring of chemicals observed in environment.https://doi.org/10.1038/s41378-024-00865-4 |
| spellingShingle | Jinsol Choi Chi Yeung Oh Gong Qian Tae Soup Shim Heon-Ho Jeong Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding Microsystems & Nanoengineering |
| title | Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding |
| title_full | Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding |
| title_fullStr | Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding |
| title_full_unstemmed | Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding |
| title_short | Optofluidic paper-based analytical device for discriminative detection of organic substances via digital color coding |
| title_sort | optofluidic paper based analytical device for discriminative detection of organic substances via digital color coding |
| url | https://doi.org/10.1038/s41378-024-00865-4 |
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