The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis

The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis

Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota dysbiosis in IBD patients, while Ptpn2 knock-out (Ptpn2-KO) m...

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Bibliographic Details
Main Authors: Pritha Chatterjee, Vinicius Canale, Stephanie J. King, Ali Shawki, Hillmin Lei, Alina N. Santos, Michael Haddad, Casey Gries, Dermot P. B. McGovern, James Borneman, Declan F. McCole
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
AIEC
LF82
JAK-STAT
gut barrier
IBD
tofacitinib
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2526136
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