TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility

TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility

Abstract Thyroid hormone receptors (TRs) mediate the genomic actions of thyroid hormone. Mutations of THRA gene cause a human disease known as resistance to thyroid hormone (RTHα). We created a mouse model expressing a dominant negative mutated TRα1 (Thra1PV/+ mice) that exhibits growth retardation,...

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Bibliographic Details
Main Authors: Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Thyroid hormone receptor α1
Female reproduction
Resistance to thyroid hormone
KLF9
Spatial transcriptomics
Endometrial metaplasia
Online Access:https://doi.org/10.1038/s41598-025-86848-5
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