NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis
Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/367694 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545437341450240 |
|---|---|
| author | Shin Maeda |
| author_facet | Shin Maeda |
| author_sort | Shin Maeda |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-κB and JNKs, is critical for tumor organization. JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC. |
| format | Article |
| id | doaj-art-5f3672ff6ed645899909f05a8ed59e96 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-5f3672ff6ed645899909f05a8ed59e962025-02-03T07:25:45ZengWileyGastroenterology Research and Practice1687-61211687-630X2010-01-01201010.1155/2010/367694367694NF-κB, JNK, and TLR Signaling Pathways in HepatocarcinogenesisShin Maeda0Department of Gastroenterology, Yokohama City University, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, JapanHepatocellular carcinoma (HCC) is the third largest cause of cancer deaths worldwide. The role of molecular changes in HCC have been used to identify prognostic markers and chemopreventive or therapeutic targets. It seems that toll-like receptors (TLRs) as well as the nuclear factor (NF)-κB, and JNK pathways are critical regulators for the production of the cytokines associated with tumor promotion. The cross-talk between an inflammatory cell and a neoplastic cell, which is instigated by the activation of NF-κB and JNKs, is critical for tumor organization. JNKs also regulate cell proliferation and act as oncogenes, making them the main tumor-promoting protein kinases. TLRs play roles in cytokine and hepatomitogen expression mainly in myeloid cells and may promote liver tumorigenesis. A better understanding of these signaling pathways in the liver will help us understand the mechanism of hepatocarcinogenesis and provide a new therapeutic target for HCC.http://dx.doi.org/10.1155/2010/367694 |
| spellingShingle | Shin Maeda NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis Gastroenterology Research and Practice |
| title | NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis |
| title_full | NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis |
| title_fullStr | NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis |
| title_full_unstemmed | NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis |
| title_short | NF-κB, JNK, and TLR Signaling Pathways in Hepatocarcinogenesis |
| title_sort | nf κb jnk and tlr signaling pathways in hepatocarcinogenesis |
| url | http://dx.doi.org/10.1155/2010/367694 |
| work_keys_str_mv | AT shinmaeda nfkbjnkandtlrsignalingpathwaysinhepatocarcinogenesis |