Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (SAH) is one of the most severe forms of stroke, which results from the rupture of a cerebral aneurysm. SAH is the only type of stroke with a female predominance, suggesting that reproductive factors may play a significant role in the etiology. Estrogen has importa...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2015/720141 |
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| _version_ | 1832562873448005632 |
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| author | Sadaharu Tabuchi |
| author_facet | Sadaharu Tabuchi |
| author_sort | Sadaharu Tabuchi |
| collection | DOAJ |
| description | Aneurysmal subarachnoid hemorrhage (SAH) is one of the most severe forms of stroke, which results from the rupture of a cerebral aneurysm. SAH is the only type of stroke with a female predominance, suggesting that reproductive factors may play a significant role in the etiology. Estrogen has important effects on vascular physiology and pathophysiology of cerebral aneurysm and SAH and, thus, potential therapeutic implications. There have been growing bodies of epidemiological and experimental studies which support the hypothesis of a significant relationship between estrogen deficiency and cerebral aneurysm formation with subsequent SAH. This hypothesis is the focus of this review as well as possible pathology-based therapeutics with regard to aspects of molecular pathophysiology, especially related to women’s health. |
| format | Article |
| id | doaj-art-5f25b5e0f7334bbf86c466b2e2875e5f |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-5f25b5e0f7334bbf86c466b2e2875e5f2025-02-03T01:21:34ZengWileyBehavioural Neurology0953-41801875-85842015-01-01201510.1155/2015/720141720141Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid HemorrhageSadaharu Tabuchi0Department of Neurosurgery, Tottori Prefectural Central Hospital, Tottori 680-0901, JapanAneurysmal subarachnoid hemorrhage (SAH) is one of the most severe forms of stroke, which results from the rupture of a cerebral aneurysm. SAH is the only type of stroke with a female predominance, suggesting that reproductive factors may play a significant role in the etiology. Estrogen has important effects on vascular physiology and pathophysiology of cerebral aneurysm and SAH and, thus, potential therapeutic implications. There have been growing bodies of epidemiological and experimental studies which support the hypothesis of a significant relationship between estrogen deficiency and cerebral aneurysm formation with subsequent SAH. This hypothesis is the focus of this review as well as possible pathology-based therapeutics with regard to aspects of molecular pathophysiology, especially related to women’s health.http://dx.doi.org/10.1155/2015/720141 |
| spellingShingle | Sadaharu Tabuchi Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage Behavioural Neurology |
| title | Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage |
| title_full | Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage |
| title_fullStr | Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage |
| title_full_unstemmed | Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage |
| title_short | Relationship between Postmenopausal Estrogen Deficiency and Aneurysmal Subarachnoid Hemorrhage |
| title_sort | relationship between postmenopausal estrogen deficiency and aneurysmal subarachnoid hemorrhage |
| url | http://dx.doi.org/10.1155/2015/720141 |
| work_keys_str_mv | AT sadaharutabuchi relationshipbetweenpostmenopausalestrogendeficiencyandaneurysmalsubarachnoidhemorrhage |