Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation
Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues. The adherens junction, a major mechanism of intercellular adhesion, is comprised of transmembrane cadherins forming homotyp...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/272858 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562112404127744 |
|---|---|
| author | Alejandro Pablo Adam |
| author_facet | Alejandro Pablo Adam |
| author_sort | Alejandro Pablo Adam |
| collection | DOAJ |
| description | Endothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues. The adherens junction, a major mechanism of intercellular adhesion, is comprised of transmembrane cadherins forming homotypic interactions between adjacent cells and associated cytoplasmic catenins linking the cadherins to the cytoskeleton. Inflammatory conditions promote the disassembly of the adherens junction and a loss of intercellular adhesion, creating openings or gaps in the endothelium through which small molecules diffuse and leukocytes transmigrate. Tyrosine kinase signaling has emerged as a central regulator of the inflammatory response, partly through direct phosphorylation and dephosphorylation of the adherens junction components. This review discusses the findings that support and those that argue against a direct effect of cadherin and catenin phosphorylation in the disassembly of the adherens junction. Recent findings indicate a complex interaction between kinases, phosphatases, and the adherens junction components that allow a fine regulation of the endothelial permeability to small molecules, leukocyte migration, and barrier resealing. |
| format | Article |
| id | doaj-art-5f2598f30c0a4adb97d0b127ead02b54 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5f2598f30c0a4adb97d0b127ead02b542025-02-03T01:23:21ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/272858272858Regulation of Endothelial Adherens Junctions by Tyrosine PhosphorylationAlejandro Pablo Adam0Center for Cardiovascular Sciences and Department of Ophthalmology, Albany Medical College, Albany, NY 12208, USAEndothelial cells form a semipermeable, regulated barrier that limits the passage of fluid, small molecules, and leukocytes between the bloodstream and the surrounding tissues. The adherens junction, a major mechanism of intercellular adhesion, is comprised of transmembrane cadherins forming homotypic interactions between adjacent cells and associated cytoplasmic catenins linking the cadherins to the cytoskeleton. Inflammatory conditions promote the disassembly of the adherens junction and a loss of intercellular adhesion, creating openings or gaps in the endothelium through which small molecules diffuse and leukocytes transmigrate. Tyrosine kinase signaling has emerged as a central regulator of the inflammatory response, partly through direct phosphorylation and dephosphorylation of the adherens junction components. This review discusses the findings that support and those that argue against a direct effect of cadherin and catenin phosphorylation in the disassembly of the adherens junction. Recent findings indicate a complex interaction between kinases, phosphatases, and the adherens junction components that allow a fine regulation of the endothelial permeability to small molecules, leukocyte migration, and barrier resealing.http://dx.doi.org/10.1155/2015/272858 |
| spellingShingle | Alejandro Pablo Adam Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation Mediators of Inflammation |
| title | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| title_full | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| title_fullStr | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| title_full_unstemmed | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| title_short | Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation |
| title_sort | regulation of endothelial adherens junctions by tyrosine phosphorylation |
| url | http://dx.doi.org/10.1155/2015/272858 |
| work_keys_str_mv | AT alejandropabloadam regulationofendothelialadherensjunctionsbytyrosinephosphorylation |