SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model

SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model

Abstract Intestinal fibrosis, as a late-stage complication of inflammatory bowel disease (IBD), leads to bowel obstruction and requires surgical intervention, significantly lowering the quality of life of affected patients. SAA3, a highly conserved member of the serum amyloid A (SAA) apolipoprotein...

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Bibliographic Details
Main Authors: Xiaodong Zou, Tong Wu, Jianjiao Lin, Tao Su, Hui Xiao, Chuyan Ni, Lijuan Hu, Wenchu Lin, Weilin Chen, Richard D. Ye, Li Xiang
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02299-x
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