Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease?
Crohn’s disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. However, infliximab therapy is expensive; therefore, identifying variables that can help predict response to in...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2009/431349 |
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| _version_ | 1832559137546829824 |
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| author | Neeraj Narula Richard N Fedorak |
| author_facet | Neeraj Narula Richard N Fedorak |
| author_sort | Neeraj Narula |
| collection | DOAJ |
| description | Crohn’s disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. However, infliximab therapy is expensive; therefore, identifying variables that can help predict response to infliximab is worthwhile. The present article reviews the impact of tobacco smoking on the efficacy of infliximab in CD. Earlier studies have speculated that smoking has a negative effect on the response to infliximab in CD, but the current literature is largely unable to identify a significant relationship between the two. Although smoking is known to have a negative effect on the course of CD, as well as other organ systems, presently, a CD patient’s smoking status should not influence treatment decisions regarding infliximab therapy. |
| format | Article |
| id | doaj-art-5f1b2be99ded46e786a0394b3b6161ec |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-5f1b2be99ded46e786a0394b3b6161ec2025-02-03T01:30:47ZengWileyCanadian Journal of Gastroenterology0835-79002009-01-0123212112510.1155/2009/431349Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease?Neeraj Narula0Richard N Fedorak1Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDivision of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaCrohn’s disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. However, infliximab therapy is expensive; therefore, identifying variables that can help predict response to infliximab is worthwhile. The present article reviews the impact of tobacco smoking on the efficacy of infliximab in CD. Earlier studies have speculated that smoking has a negative effect on the response to infliximab in CD, but the current literature is largely unable to identify a significant relationship between the two. Although smoking is known to have a negative effect on the course of CD, as well as other organ systems, presently, a CD patient’s smoking status should not influence treatment decisions regarding infliximab therapy.http://dx.doi.org/10.1155/2009/431349 |
| spellingShingle | Neeraj Narula Richard N Fedorak Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? Canadian Journal of Gastroenterology |
| title | Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? |
| title_full | Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? |
| title_fullStr | Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? |
| title_full_unstemmed | Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? |
| title_short | Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? |
| title_sort | does smoking reduce infliximab s effectiveness against crohn s disease |
| url | http://dx.doi.org/10.1155/2009/431349 |
| work_keys_str_mv | AT neerajnarula doessmokingreduceinfliximabseffectivenessagainstcrohnsdisease AT richardnfedorak doessmokingreduceinfliximabseffectivenessagainstcrohnsdisease |