Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge
Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/6207487 |
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| _version_ | 1832564608950337536 |
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| author | Steven De Keukeleire Daniëlle Borrey Wim Decaluwe Marijke Reynders |
| author_facet | Steven De Keukeleire Daniëlle Borrey Wim Decaluwe Marijke Reynders |
| author_sort | Steven De Keukeleire |
| collection | DOAJ |
| description | Necrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when treating pathogens with elevated MIC. As safe as meropenem is, there are not enough data for 40 mg/kg, every 8 h infused over 4 h; accordingly, strict monitoring of blood levels is mandatory. Based on our findings, a 4 h prolonged infusion of 40 mg/kg meropenem, every 8 h, will achieve an adequate patient outcome. |
| format | Article |
| id | doaj-art-5f1250b443c548d3a007b86490527675 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-5f1250b443c548d3a007b864905276752025-02-03T01:10:41ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/62074876207487Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A ChallengeSteven De Keukeleire0Daniëlle Borrey1Wim Decaluwe2Marijke Reynders3Department of Laboratory Medicine, AZ Sint-Jan Bruges, Bruges, BelgiumDepartment of Laboratory Medicine, AZ Sint-Jan Bruges, Bruges, BelgiumDepartment of Pediatrics, Neonatal Intensive Care, AZ Sint-Jan Bruges, Bruges, BelgiumDepartment of Laboratory Medicine, AZ Sint-Jan Bruges, Bruges, BelgiumNecrotizing enterocolitis (NEC) continues to be a major cause of neonatal morbidity and mortality. We describe the added value of therapeutic drug monitoring by presenting the case of a preterm infant with severe NEC treated with meropenem. Dosing strategy will achieve adequate patient outcome when treating pathogens with elevated MIC. As safe as meropenem is, there are not enough data for 40 mg/kg, every 8 h infused over 4 h; accordingly, strict monitoring of blood levels is mandatory. Based on our findings, a 4 h prolonged infusion of 40 mg/kg meropenem, every 8 h, will achieve an adequate patient outcome.http://dx.doi.org/10.1155/2016/6207487 |
| spellingShingle | Steven De Keukeleire Daniëlle Borrey Wim Decaluwe Marijke Reynders Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge Case Reports in Infectious Diseases |
| title | Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge |
| title_full | Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge |
| title_fullStr | Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge |
| title_full_unstemmed | Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge |
| title_short | Therapeutic Drug Monitoring of Meropenem in Neonate with Necrotizing Enterocolitis: A Challenge |
| title_sort | therapeutic drug monitoring of meropenem in neonate with necrotizing enterocolitis a challenge |
| url | http://dx.doi.org/10.1155/2016/6207487 |
| work_keys_str_mv | AT stevendekeukeleire therapeuticdrugmonitoringofmeropeneminneonatewithnecrotizingenterocolitisachallenge AT danielleborrey therapeuticdrugmonitoringofmeropeneminneonatewithnecrotizingenterocolitisachallenge AT wimdecaluwe therapeuticdrugmonitoringofmeropeneminneonatewithnecrotizingenterocolitisachallenge AT marijkereynders therapeuticdrugmonitoringofmeropeneminneonatewithnecrotizingenterocolitisachallenge |