Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines
The use of nanoparticles encapsulating messenger RNA (mRNA) as a vaccine has recently attracted much attention because of encouraging results achieved in many nonviral genetic antitumor vaccination studies. Notably, in all of these studies, mRNA nanoparticles are passively targeted to dendritic cell...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/680620 |
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| _version_ | 1832552853752774656 |
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| author | Kyle K. L. Phua |
| author_facet | Kyle K. L. Phua |
| author_sort | Kyle K. L. Phua |
| collection | DOAJ |
| description | The use of nanoparticles encapsulating messenger RNA (mRNA) as a vaccine has recently attracted much attention because of encouraging results achieved in many nonviral genetic antitumor vaccination studies. Notably, in all of these studies, mRNA nanoparticles are passively targeted to dendritic cells (DCs) through careful selection of vaccination sites. Hence, DC-targeted mRNA nanoparticle vaccines may be an imminent next step forward. In this brief report, we will discuss established conjugation strategies that have been successfully applied to both polymeric and liposomal gene delivery systems. We will also briefly describe promising DC surface receptors amenable for targeting mRNA nanoparticles. Practicable conjugation strategies and receptors reviewed in this paper will provide a convenient reference to facilitate future development of targeted mRNA nanoparticle vaccine. |
| format | Article |
| id | doaj-art-5f07eda69654402fa9483729c7eda0ed |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5f07eda69654402fa9483729c7eda0ed2025-02-03T05:57:41ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/680620680620Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor VaccinesKyle K. L. Phua0Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 3, 117583, SingaporeThe use of nanoparticles encapsulating messenger RNA (mRNA) as a vaccine has recently attracted much attention because of encouraging results achieved in many nonviral genetic antitumor vaccination studies. Notably, in all of these studies, mRNA nanoparticles are passively targeted to dendritic cells (DCs) through careful selection of vaccination sites. Hence, DC-targeted mRNA nanoparticle vaccines may be an imminent next step forward. In this brief report, we will discuss established conjugation strategies that have been successfully applied to both polymeric and liposomal gene delivery systems. We will also briefly describe promising DC surface receptors amenable for targeting mRNA nanoparticles. Practicable conjugation strategies and receptors reviewed in this paper will provide a convenient reference to facilitate future development of targeted mRNA nanoparticle vaccine.http://dx.doi.org/10.1155/2015/680620 |
| spellingShingle | Kyle K. L. Phua Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines Journal of Immunology Research |
| title | Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines |
| title_full | Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines |
| title_fullStr | Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines |
| title_full_unstemmed | Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines |
| title_short | Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines |
| title_sort | towards targeted delivery systems ligand conjugation strategies for mrna nanoparticle tumor vaccines |
| url | http://dx.doi.org/10.1155/2015/680620 |
| work_keys_str_mv | AT kyleklphua towardstargeteddeliverysystemsligandconjugationstrategiesformrnananoparticletumorvaccines |