Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTβR). We found that LIGHT is critical for control of hepatic parasite growth in mi...

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Main Authors: Amanda C Stanley, Fabian de Labastida Rivera, Ashraful Haque, Meru Sheel, Yonghong Zhou, Fiona H Amante, Patrick T Bunn, Louise M Randall, Klaus Pfeffer, Stefanie Scheu, Michael J Hickey, Bernadette M Saunders, Carl Ware, Geoff R Hill, Koji Tamada, Paul M Kaye, Christian R Engwerda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-10-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002279&type=printable
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