To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents
Ischemic strokes are major causes of death and disability. Searching for potential therapeutic strategies to prevent and treat stroke is necessary, given the increase in overall life expectancy. Epidemiological reports indicate that metformin is an oral antidiabetic medication that can reduce the in...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2017/9756429 |
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| author | Isaac Arbeláez-Quintero Mauricio Palacios |
| author_facet | Isaac Arbeláez-Quintero Mauricio Palacios |
| author_sort | Isaac Arbeláez-Quintero |
| collection | DOAJ |
| description | Ischemic strokes are major causes of death and disability. Searching for potential therapeutic strategies to prevent and treat stroke is necessary, given the increase in overall life expectancy. Epidemiological reports indicate that metformin is an oral antidiabetic medication that can reduce the incidence of ischemic events in patients with diabetes mellitus. Its mechanism of action has not been elucidated, but metformin pleiotropic effects involve actions in addition to glycemic control. AMPK activation has been described as one of the pharmacological mechanisms that explain the action of metformin and that lead to neuroprotective effects. Most experiments done in the cerebral ischemia model, via middle cerebral artery occlusion in rodents (MCAO), had positive results favoring metformin’s neuroprotective role and involve several cellular pathways like oxidative stress, endothelial nitric oxide synthase activation, activation of angiogenesis and neurogenesis, autophagia, and apoptosis. We will review the pharmacological properties of metformin and its possible mechanisms that lead to neuroprotection in cerebral ischemia. |
| format | Article |
| id | doaj-art-5ef3f0a5d2134e9eb91b9585b9e33017 |
| institution | Kabale University |
| issn | 2090-8105 2042-0056 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-5ef3f0a5d2134e9eb91b9585b9e330172025-02-03T01:20:46ZengWileyStroke Research and Treatment2090-81052042-00562017-01-01201710.1155/2017/97564299756429To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke RodentsIsaac Arbeláez-Quintero0Mauricio Palacios1Centro de Estudios Cerebrales, Facultad de Salud, Universidad del Valle, Cali, ColombiaCentro de Estudios Cerebrales, Facultad de Salud, Universidad del Valle, Cali, ColombiaIschemic strokes are major causes of death and disability. Searching for potential therapeutic strategies to prevent and treat stroke is necessary, given the increase in overall life expectancy. Epidemiological reports indicate that metformin is an oral antidiabetic medication that can reduce the incidence of ischemic events in patients with diabetes mellitus. Its mechanism of action has not been elucidated, but metformin pleiotropic effects involve actions in addition to glycemic control. AMPK activation has been described as one of the pharmacological mechanisms that explain the action of metformin and that lead to neuroprotective effects. Most experiments done in the cerebral ischemia model, via middle cerebral artery occlusion in rodents (MCAO), had positive results favoring metformin’s neuroprotective role and involve several cellular pathways like oxidative stress, endothelial nitric oxide synthase activation, activation of angiogenesis and neurogenesis, autophagia, and apoptosis. We will review the pharmacological properties of metformin and its possible mechanisms that lead to neuroprotection in cerebral ischemia.http://dx.doi.org/10.1155/2017/9756429 |
| spellingShingle | Isaac Arbeláez-Quintero Mauricio Palacios To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents Stroke Research and Treatment |
| title | To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents |
| title_full | To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents |
| title_fullStr | To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents |
| title_full_unstemmed | To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents |
| title_short | To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents |
| title_sort | to use or not to use metformin in cerebral ischemia a review of the application of metformin in stroke rodents |
| url | http://dx.doi.org/10.1155/2017/9756429 |
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