Analytical Methods Used for the Detection and Quantification of Benzodiazepines
The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these d...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Analytical Methods in Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/2035492 |
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| author | Zidane Qriouet Zineb Qmichou Nadia Bouchoutrouch Hassan Mahi Yahia Cherrah Hassan Sefrioui |
| author_facet | Zidane Qriouet Zineb Qmichou Nadia Bouchoutrouch Hassan Mahi Yahia Cherrah Hassan Sefrioui |
| author_sort | Zidane Qriouet |
| collection | DOAJ |
| description | The prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, leading to a lot of drug abuse amongst some addicted users, road insecurity, and suicide. Hence, it has become essential to analyze the BZDs drugs in human biological specimens for drug abuse in forensic sciences. The present review provides a summary of sample preparation techniques (solid-phase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules in the commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. The commonly used methods for the detection and quantification of BZDs include nuclear magnetic resonance (NMR), chromatography (GC-MS, HPLC, and TLC), immunoassay (ELISA, RIA, LFA, CEDEA, FPIA, and KIMS), and electroanalytical methods (voltammetry and potentiometry). |
| format | Article |
| id | doaj-art-5ef341de226a4504bf5c6302a3145df6 |
| institution | Kabale University |
| issn | 2090-8865 2090-8873 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Analytical Methods in Chemistry |
| spelling | doaj-art-5ef341de226a4504bf5c6302a3145df62025-02-03T07:24:40ZengWileyJournal of Analytical Methods in Chemistry2090-88652090-88732019-01-01201910.1155/2019/20354922035492Analytical Methods Used for the Detection and Quantification of BenzodiazepinesZidane Qriouet0Zineb Qmichou1Nadia Bouchoutrouch2Hassan Mahi3Yahia Cherrah4Hassan Sefrioui5Medical Biotechnology Center, Moroccan Foundation for Science, Innovation & Research (MAScIR), Rabat, MoroccoMedical Biotechnology Center, Moroccan Foundation for Science, Innovation & Research (MAScIR), Rabat, MoroccoMedical Biotechnology Center, Moroccan Foundation for Science, Innovation & Research (MAScIR), Rabat, MoroccoMedical Biotechnology Center, Moroccan Foundation for Science, Innovation & Research (MAScIR), Rabat, MoroccoLaboratoire de Pharmacologie et Toxicologie, Faculté de Médecine et de Pharmacie, Université Mohammed V-Souissi, Rabat, MoroccoMedical Biotechnology Center, Moroccan Foundation for Science, Innovation & Research (MAScIR), Rabat, MoroccoThe prescription of psychotropic drugs, especially benzodiazepines (BZDs), occupies a preponderant place in the management of mental illnesses. Indeed, the BZDs have been used in different therapeutic areas including insomnia, anxiety, seizure disorders, or general anesthesia. Unfortunately, these drugs are present in the illegal street market, leading to a lot of drug abuse amongst some addicted users, road insecurity, and suicide. Hence, it has become essential to analyze the BZDs drugs in human biological specimens for drug abuse in forensic sciences. The present review provides a summary of sample preparation techniques (solid-phase extraction and Liquid-liquid phase extraction) and the methods for the detection and quantification of BZDs molecules in the commonly used biological specimens over the ten last years which may potentially lead to better and accurate evaluation of the physiological state of a given person. The commonly used methods for the detection and quantification of BZDs include nuclear magnetic resonance (NMR), chromatography (GC-MS, HPLC, and TLC), immunoassay (ELISA, RIA, LFA, CEDEA, FPIA, and KIMS), and electroanalytical methods (voltammetry and potentiometry).http://dx.doi.org/10.1155/2019/2035492 |
| spellingShingle | Zidane Qriouet Zineb Qmichou Nadia Bouchoutrouch Hassan Mahi Yahia Cherrah Hassan Sefrioui Analytical Methods Used for the Detection and Quantification of Benzodiazepines Journal of Analytical Methods in Chemistry |
| title | Analytical Methods Used for the Detection and Quantification of Benzodiazepines |
| title_full | Analytical Methods Used for the Detection and Quantification of Benzodiazepines |
| title_fullStr | Analytical Methods Used for the Detection and Quantification of Benzodiazepines |
| title_full_unstemmed | Analytical Methods Used for the Detection and Quantification of Benzodiazepines |
| title_short | Analytical Methods Used for the Detection and Quantification of Benzodiazepines |
| title_sort | analytical methods used for the detection and quantification of benzodiazepines |
| url | http://dx.doi.org/10.1155/2019/2035492 |
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