Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy
Background: Postpartum cardiomyopathy is defined as an incident of acute heart failure in the postpartum period in the absence of any other cause. Up to 10% of postpartum cardiomyopathy may need to undergo heart transplantation later in life. This study aimed to provide a present-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-01-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25831 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586509962706944 |
|---|---|
| author | Ilias P. Doulamis Aspasia Tzani Ahmet Kilic Toshiki Kuno Alexandros Briasoulis |
| author_facet | Ilias P. Doulamis Aspasia Tzani Ahmet Kilic Toshiki Kuno Alexandros Briasoulis |
| author_sort | Ilias P. Doulamis |
| collection | DOAJ |
| description | Background: Postpartum cardiomyopathy is defined as an incident of acute heart failure in the postpartum period in the absence of any other cause. Up to 10% of postpartum cardiomyopathy may need to undergo heart transplantation later in life. This study aimed to provide a present-day perspective on all-cause mortality and transplant-related complications after heart transplantation for postpartum cardiomyopathy. Methods: A retrospective analysis of the United Network for Organ Sharing (UNOS) registry was performed for adult patients undergoing heart transplants (01/2001–01/2023) for postpartum cardiomyopathy. Results: A total of 677 patients were identified, with a mean age of 35 years. The mean body mass index (BMI) was 27.2 kg/m2; the most common comorbidity was type 2 diabetes (T2D) (n = 589; 87%). Older age was associated with lower overall mortality (hazard ratio (HR): 0.97; 95% CI: 0.95, 0.98; p < 0.01), while diabetes (HR: 1.01; 95% CI: 1.01, 1.01; p < 0.01), dialysis (HR: 1.01; 95% CI: 1.01, 1.01; p < 0.01), days on Status 1 on the UNOS registry (HR: 1.06; 95% CI: 1.03, 10.9; p < 0.01), creatinine (HR: 1.29; 95% CI: 1.02, 1.64; p = 0.034), and length of stay (HR: 1.01; 95% CI: 1.01, 1.02; p = 0.02) were associated with a higher risk of overall mortality. Moreover, 30-day mortality was 2.8%, and 1-year mortality was 11.1%. The era effect was prominent in cases of 1-year mortality (odds ratio (OR): 0.95; 95% CI: 0.91, 0.99, p = 0.006). Conclusions: Our results suggest that younger age, diabetes, pretransplant dialysis, days on Status 1, and creatinine are associated with higher mortality, while an era effect was observed for 1-year mortality after heart transplantation (HTx) in patients with postpartum cardiomyopathy. |
| format | Article |
| id | doaj-art-5ef2f00aa9974583beb13287895e86b8 |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-5ef2f00aa9974583beb13287895e86b82025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612583110.31083/RCM25831S1530-6550(24)01633-8Nationwide Outcomes of Heart Transplantation for Postpartum CardiomyopathyIlias P. Doulamis0Aspasia Tzani1Ahmet Kilic2Toshiki Kuno3Alexandros Briasoulis4Department of Surgery, Lahey Clinic, Burlington, MA 01805, USADepartment of Cardiovascular Medicine, Brigham and Women’s Hospital Heart and Vascular Center, Harvard Medical School, Boston, MA 02115, USADivison of Cardiothoracic Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADivision of Cardiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY 10467, USADivision of Cardiovascular Medicine, Section of Heart Failure and Transplantation, University of Iowa, Iowa City, IA 52242, USABackground: Postpartum cardiomyopathy is defined as an incident of acute heart failure in the postpartum period in the absence of any other cause. Up to 10% of postpartum cardiomyopathy may need to undergo heart transplantation later in life. This study aimed to provide a present-day perspective on all-cause mortality and transplant-related complications after heart transplantation for postpartum cardiomyopathy. Methods: A retrospective analysis of the United Network for Organ Sharing (UNOS) registry was performed for adult patients undergoing heart transplants (01/2001–01/2023) for postpartum cardiomyopathy. Results: A total of 677 patients were identified, with a mean age of 35 years. The mean body mass index (BMI) was 27.2 kg/m2; the most common comorbidity was type 2 diabetes (T2D) (n = 589; 87%). Older age was associated with lower overall mortality (hazard ratio (HR): 0.97; 95% CI: 0.95, 0.98; p < 0.01), while diabetes (HR: 1.01; 95% CI: 1.01, 1.01; p < 0.01), dialysis (HR: 1.01; 95% CI: 1.01, 1.01; p < 0.01), days on Status 1 on the UNOS registry (HR: 1.06; 95% CI: 1.03, 10.9; p < 0.01), creatinine (HR: 1.29; 95% CI: 1.02, 1.64; p = 0.034), and length of stay (HR: 1.01; 95% CI: 1.01, 1.02; p = 0.02) were associated with a higher risk of overall mortality. Moreover, 30-day mortality was 2.8%, and 1-year mortality was 11.1%. The era effect was prominent in cases of 1-year mortality (odds ratio (OR): 0.95; 95% CI: 0.91, 0.99, p = 0.006). Conclusions: Our results suggest that younger age, diabetes, pretransplant dialysis, days on Status 1, and creatinine are associated with higher mortality, while an era effect was observed for 1-year mortality after heart transplantation (HTx) in patients with postpartum cardiomyopathy.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25831unosheart transplantationpostpartum cardiomyopathy |
| spellingShingle | Ilias P. Doulamis Aspasia Tzani Ahmet Kilic Toshiki Kuno Alexandros Briasoulis Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy Reviews in Cardiovascular Medicine unos heart transplantation postpartum cardiomyopathy |
| title | Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy |
| title_full | Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy |
| title_fullStr | Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy |
| title_full_unstemmed | Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy |
| title_short | Nationwide Outcomes of Heart Transplantation for Postpartum Cardiomyopathy |
| title_sort | nationwide outcomes of heart transplantation for postpartum cardiomyopathy |
| topic | unos heart transplantation postpartum cardiomyopathy |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM25831 |
| work_keys_str_mv | AT iliaspdoulamis nationwideoutcomesofhearttransplantationforpostpartumcardiomyopathy AT aspasiatzani nationwideoutcomesofhearttransplantationforpostpartumcardiomyopathy AT ahmetkilic nationwideoutcomesofhearttransplantationforpostpartumcardiomyopathy AT toshikikuno nationwideoutcomesofhearttransplantationforpostpartumcardiomyopathy AT alexandrosbriasoulis nationwideoutcomesofhearttransplantationforpostpartumcardiomyopathy |