Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria
Anaemia is a common morbidity in the NICU and often requires transfusion of packed red blood cells. Haematocrit equilibration following red cell transfusion occurs over time ultimately resulting in a stable packed cell volume (PCV). Knowledge of this equilibration process is pertinent in the accurat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2015/175867 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555467811848192 |
|---|---|
| author | L. I. Audu A. T. Otuneye A. B. Mairami L. J. Mshelia V. E. Nwatah |
| author_facet | L. I. Audu A. T. Otuneye A. B. Mairami L. J. Mshelia V. E. Nwatah |
| author_sort | L. I. Audu |
| collection | DOAJ |
| description | Anaemia is a common morbidity in the NICU and often requires transfusion of packed red blood cells. Haematocrit equilibration following red cell transfusion occurs over time ultimately resulting in a stable packed cell volume (PCV). Knowledge of this equilibration process is pertinent in the accurate timing of posttransfusion (PT) PCV. We conducted a prospective study to determine an appropriate timing for PT PCV estimation on 47 stable anaemic babies at the Neonatal Unit of National Hospital, Abuja. Values of PCV were determined before transfusion and at 1, 6, 12, 24, and 48 hours posttransfusion. Forty of the recruited neonates and young infants were analyzed. Their gestational age range was 26 to 40 weeks. 1-hour PT PCV (48.5% ± 5.5%) was similar to the 6-hour PT PCV (47.8% ± 5.6%) P=0.516, but both were significantly different from the 12-hour (46.8% ± 5.9%), 24-hour (45.9 ± 5.8%), and 48-hour (45.4% ± 6.2%) PT PCVs. The 12-hour PT PCV was similar to the 24-hour and 48-hour PT PCVs (P=0.237 and 0.063, resp.). We concluded that, in stable nonhaemorrhaging and nonhaemolysing young infants, the estimated timing of haematocrit equilibration and, consequently, posttransfusion PCV is 12 hours after red blood cell transfusion. |
| format | Article |
| id | doaj-art-5eebc1757a7843399fb7577bf21cb831 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-5eebc1757a7843399fb7577bf21cb8312025-02-03T05:48:09ZengWileyInternational Journal of Pediatrics1687-97401687-97592015-01-01201510.1155/2015/175867175867Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, NigeriaL. I. Audu0A. T. Otuneye1A. B. Mairami2L. J. Mshelia3V. E. Nwatah4Neonatal Unit, National Hospital Abuja, Plot 132, National Hospital Road, Central Business District, PMB 425, Abuja, NigeriaNeonatal Unit, National Hospital Abuja, Plot 132, National Hospital Road, Central Business District, PMB 425, Abuja, NigeriaNeonatal Unit, National Hospital Abuja, Plot 132, National Hospital Road, Central Business District, PMB 425, Abuja, NigeriaNeonatal Unit, National Hospital Abuja, Plot 132, National Hospital Road, Central Business District, PMB 425, Abuja, NigeriaNeonatal Unit, National Hospital Abuja, Plot 132, National Hospital Road, Central Business District, PMB 425, Abuja, NigeriaAnaemia is a common morbidity in the NICU and often requires transfusion of packed red blood cells. Haematocrit equilibration following red cell transfusion occurs over time ultimately resulting in a stable packed cell volume (PCV). Knowledge of this equilibration process is pertinent in the accurate timing of posttransfusion (PT) PCV. We conducted a prospective study to determine an appropriate timing for PT PCV estimation on 47 stable anaemic babies at the Neonatal Unit of National Hospital, Abuja. Values of PCV were determined before transfusion and at 1, 6, 12, 24, and 48 hours posttransfusion. Forty of the recruited neonates and young infants were analyzed. Their gestational age range was 26 to 40 weeks. 1-hour PT PCV (48.5% ± 5.5%) was similar to the 6-hour PT PCV (47.8% ± 5.6%) P=0.516, but both were significantly different from the 12-hour (46.8% ± 5.9%), 24-hour (45.9 ± 5.8%), and 48-hour (45.4% ± 6.2%) PT PCVs. The 12-hour PT PCV was similar to the 24-hour and 48-hour PT PCVs (P=0.237 and 0.063, resp.). We concluded that, in stable nonhaemorrhaging and nonhaemolysing young infants, the estimated timing of haematocrit equilibration and, consequently, posttransfusion PCV is 12 hours after red blood cell transfusion.http://dx.doi.org/10.1155/2015/175867 |
| spellingShingle | L. I. Audu A. T. Otuneye A. B. Mairami L. J. Mshelia V. E. Nwatah Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria International Journal of Pediatrics |
| title | Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria |
| title_full | Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria |
| title_fullStr | Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria |
| title_full_unstemmed | Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria |
| title_short | Posttransfusion Haematocrit Equilibration: Timing Posttransfusion Haematocrit Check in Neonates at the National Hospital, Abuja, Nigeria |
| title_sort | posttransfusion haematocrit equilibration timing posttransfusion haematocrit check in neonates at the national hospital abuja nigeria |
| url | http://dx.doi.org/10.1155/2015/175867 |
| work_keys_str_mv | AT liaudu posttransfusionhaematocritequilibrationtimingposttransfusionhaematocritcheckinneonatesatthenationalhospitalabujanigeria AT atotuneye posttransfusionhaematocritequilibrationtimingposttransfusionhaematocritcheckinneonatesatthenationalhospitalabujanigeria AT abmairami posttransfusionhaematocritequilibrationtimingposttransfusionhaematocritcheckinneonatesatthenationalhospitalabujanigeria AT ljmshelia posttransfusionhaematocritequilibrationtimingposttransfusionhaematocritcheckinneonatesatthenationalhospitalabujanigeria AT venwatah posttransfusionhaematocritequilibrationtimingposttransfusionhaematocritcheckinneonatesatthenationalhospitalabujanigeria |