Integrated single-cell and bulk transcriptome analysis reveal lactate metabolism-related signature and T cell alteration in atrial fibrillation

Integrated single-cell and bulk transcriptome analysis reveal lactate metabolism-related signature and T cell alteration in atrial fibrillation

BackgroundAtrial fibrillation (AF) is linked to modifications in T cell-mediated immunity. Although lactate metabolism influences T cell differentiation and function, its specific role in AF and associated immune processes remains inadequately understood.MethodsWe performed an integrated transcripto...

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Bibliographic Details
Main Authors: Xianglin Long, Junxi Li, Yeshen Zhang, Zhihui Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
atrial fibrillation
lactate metabolism
t cell
transcriptomics
immunemetabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1644702/full
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