Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions
The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, s...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/983814 |
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| author | M. Snel J. T. Jonker J. Schoones H. Lamb A. de Roos H. Pijl J. W. A. Smit A. E. Meinders I. M. Jazet |
| author_facet | M. Snel J. T. Jonker J. Schoones H. Lamb A. de Roos H. Pijl J. W. A. Smit A. E. Meinders I. M. Jazet |
| author_sort | M. Snel |
| collection | DOAJ |
| description | The storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions. |
| format | Article |
| id | doaj-art-5edb6972920147e2b1315bde0f347c46 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-5edb6972920147e2b1315bde0f347c462025-02-03T05:59:34ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/983814983814Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle InterventionsM. Snel0J. T. Jonker1J. Schoones2H. Lamb3A. de Roos4H. Pijl5J. W. A. Smit6A. E. Meinders7I. M. Jazet8Departments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsWalaeus Library, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartment of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsDepartments of Endocrinology & Metabolism and General Internal Medicine, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The NetherlandsThe storage of triglyceride (TG) droplets in nonadipose tissues is called ectopic fat storage. Ectopic fat is associated with insulin resistance and type 2 diabetes mellitus (T2DM). Not the triglycerides per se but the accumulation of intermediates of lipid metabolism in organs, such as the liver, skeletal muscle, and heart seem to disrupt metabolic processes and impair organ function. We describe the mechanisms of ectopic fat depositions in the liver, skeletal muscle, and in and around the heart and the consequences for each organs function. In addition, we systematically reviewed the literature for the effects of diet-induced weight loss and exercise on ectopic fat depositions.http://dx.doi.org/10.1155/2012/983814 |
| spellingShingle | M. Snel J. T. Jonker J. Schoones H. Lamb A. de Roos H. Pijl J. W. A. Smit A. E. Meinders I. M. Jazet Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions International Journal of Endocrinology |
| title | Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions |
| title_full | Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions |
| title_fullStr | Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions |
| title_full_unstemmed | Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions |
| title_short | Ectopic Fat and Insulin Resistance: Pathophysiology and Effect of Diet and Lifestyle Interventions |
| title_sort | ectopic fat and insulin resistance pathophysiology and effect of diet and lifestyle interventions |
| url | http://dx.doi.org/10.1155/2012/983814 |
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