Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity
4-Thiazolidinones have been prepared by the reaction of various substituted Schiff bases 3 with Thioglycolic acid and Thiolactic acid. The intermediate Schiff bases 3 were synthesized by the condensation of various substituted 2-amino benzothiazole 1 with 1-(4'-methyl Phenyl)-3-methyl-5-pyrazol...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2004/590439 |
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| author | K. M. Mistry K. R. Desai |
| author_facet | K. M. Mistry K. R. Desai |
| author_sort | K. M. Mistry |
| collection | DOAJ |
| description | 4-Thiazolidinones have been prepared by the reaction of various substituted Schiff bases 3 with Thioglycolic acid and Thiolactic acid. The intermediate Schiff bases 3 were synthesized by the condensation of various substituted 2-amino benzothiazole 1 with 1-(4'-methyl Phenyl)-3-methyl-5-pyrazolone 2. The starting compound substituted 2-amino benzothiazoles were prepared from various substituted amines via substituted phenyl thiourea. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coli. |
| format | Article |
| id | doaj-art-5ed6b5ba297045ff9ff33522d15f1a07 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-5ed6b5ba297045ff9ff33522d15f1a072025-02-03T06:07:26ZengWileyE-Journal of Chemistry0973-49452090-98102004-01-011418919310.1155/2004/590439Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial ActivityK. M. Mistry0K. R. Desai1Department of Chemistry, South Gujarat University, Surat-395 007, IndiaDepartment of Chemistry, South Gujarat University, Surat-395 007, India4-Thiazolidinones have been prepared by the reaction of various substituted Schiff bases 3 with Thioglycolic acid and Thiolactic acid. The intermediate Schiff bases 3 were synthesized by the condensation of various substituted 2-amino benzothiazole 1 with 1-(4'-methyl Phenyl)-3-methyl-5-pyrazolone 2. The starting compound substituted 2-amino benzothiazoles were prepared from various substituted amines via substituted phenyl thiourea. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coli.http://dx.doi.org/10.1155/2004/590439 |
| spellingShingle | K. M. Mistry K. R. Desai Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity E-Journal of Chemistry |
| title | Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity |
| title_full | Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity |
| title_fullStr | Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity |
| title_full_unstemmed | Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity |
| title_short | Synthesis of Novel Heterocyclic 4-Thiazolidinone Derivatives and their Antibacterial Activity |
| title_sort | synthesis of novel heterocyclic 4 thiazolidinone derivatives and their antibacterial activity |
| url | http://dx.doi.org/10.1155/2004/590439 |
| work_keys_str_mv | AT kmmistry synthesisofnovelheterocyclic4thiazolidinonederivativesandtheirantibacterialactivity AT krdesai synthesisofnovelheterocyclic4thiazolidinonederivativesandtheirantibacterialactivity |