Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022
Duck circovirus (DuCV) infections cause immunosuppression in ducks, potentially leading to significant economic losses for the duck farming industry. This study investigates the prevalence, genetic characteristics, and evolutionary trends of DuCV in Korea between 2013 and 2022. Samples from 184 farm...
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2024-12-01
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| author | Cheng-Dong Yu Sang-Won Kim Cun-Xia Liu Yue-Hua Gao Yu-Feng Li Jong-Yeol Park Se-Yeoun Cha Hyung-Kwan Jang Min Kang Bai Wei |
| author_facet | Cheng-Dong Yu Sang-Won Kim Cun-Xia Liu Yue-Hua Gao Yu-Feng Li Jong-Yeol Park Se-Yeoun Cha Hyung-Kwan Jang Min Kang Bai Wei |
| author_sort | Cheng-Dong Yu |
| collection | DOAJ |
| description | Duck circovirus (DuCV) infections cause immunosuppression in ducks, potentially leading to significant economic losses for the duck farming industry. This study investigates the prevalence, genetic characteristics, and evolutionary trends of DuCV in Korea between 2013 and 2022. Samples from 184 farms across seven provinces were analyzed using polymerase chain reaction (PCR). The overall DuCV infection rate was 29.4% (54/184), with Jeollanam-do showing the highest prevalence (37.5%, 15/40). Ducks aged 3–6 weeks were most susceptible to infection, while ducklings younger than one week were rarely infected. Whole-genome sequencing was performed on 24 positive samples with phylogenetic analysis revealing that DuCV-1b is the predominant subtype in Korea (23/24 strains). Notably, a Korean DuCV-1a subtype strain was identified for the first time, showing close genetic relatedness to Chinese DuCV 1a strains. Novel subtype-specific amino acid variations in ORF1 and ORF2 were statistically analyzed and classified. Recombination analysis suggested some Korean DuCV-1b strains may have resulted from recombination events involving strains from different countries. This comprehensive study provides crucial insights into the current prevalence, genetic diversity, and evolutionary dynamics of DuCV in Korea, offering valuable data for developing effective control strategies and understanding the global epidemiology of this economically important avian pathogen. |
| format | Article |
| id | doaj-art-5ed032e0f46e426cb84295cae3ebf87f |
| institution | DOAJ |
| issn | 2076-2615 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Animals |
| spelling | doaj-art-5ed032e0f46e426cb84295cae3ebf87f2025-08-20T02:50:52ZengMDPI AGAnimals2076-26152024-12-011424363010.3390/ani14243630Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022Cheng-Dong Yu0Sang-Won Kim1Cun-Xia Liu2Yue-Hua Gao3Yu-Feng Li4Jong-Yeol Park5Se-Yeoun Cha6Hyung-Kwan Jang7Min Kang8Bai Wei9Department of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaInstitute of Poultry Science, Shandong Academy of Agricultural Sciences/Shandong Provincial Key Laboratory of Livestock and Poultry Breeding, Jinan 250100, ChinaInstitute of Poultry Science, Shandong Academy of Agricultural Sciences/Shandong Provincial Key Laboratory of Livestock and Poultry Breeding, Jinan 250100, ChinaInstitute of Poultry Science, Shandong Academy of Agricultural Sciences/Shandong Provincial Key Laboratory of Livestock and Poultry Breeding, Jinan 250100, ChinaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDepartment of Avian Diseases, College of Veterinary Medicine and Center for Avian Disease, Jeonbuk National University, Iksan 54596, Republic of KoreaDuck circovirus (DuCV) infections cause immunosuppression in ducks, potentially leading to significant economic losses for the duck farming industry. This study investigates the prevalence, genetic characteristics, and evolutionary trends of DuCV in Korea between 2013 and 2022. Samples from 184 farms across seven provinces were analyzed using polymerase chain reaction (PCR). The overall DuCV infection rate was 29.4% (54/184), with Jeollanam-do showing the highest prevalence (37.5%, 15/40). Ducks aged 3–6 weeks were most susceptible to infection, while ducklings younger than one week were rarely infected. Whole-genome sequencing was performed on 24 positive samples with phylogenetic analysis revealing that DuCV-1b is the predominant subtype in Korea (23/24 strains). Notably, a Korean DuCV-1a subtype strain was identified for the first time, showing close genetic relatedness to Chinese DuCV 1a strains. Novel subtype-specific amino acid variations in ORF1 and ORF2 were statistically analyzed and classified. Recombination analysis suggested some Korean DuCV-1b strains may have resulted from recombination events involving strains from different countries. This comprehensive study provides crucial insights into the current prevalence, genetic diversity, and evolutionary dynamics of DuCV in Korea, offering valuable data for developing effective control strategies and understanding the global epidemiology of this economically important avian pathogen.https://www.mdpi.com/2076-2615/14/24/3630duck circovirusepidemiological investigationphylogenetic analysisgenetic diversityrecombination |
| spellingShingle | Cheng-Dong Yu Sang-Won Kim Cun-Xia Liu Yue-Hua Gao Yu-Feng Li Jong-Yeol Park Se-Yeoun Cha Hyung-Kwan Jang Min Kang Bai Wei Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 Animals duck circovirus epidemiological investigation phylogenetic analysis genetic diversity recombination |
| title | Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 |
| title_full | Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 |
| title_fullStr | Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 |
| title_full_unstemmed | Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 |
| title_short | Epidemiological Investigation and Genetic Analysis of Duck Circovirus in Korea from 2013 to 2022 |
| title_sort | epidemiological investigation and genetic analysis of duck circovirus in korea from 2013 to 2022 |
| topic | duck circovirus epidemiological investigation phylogenetic analysis genetic diversity recombination |
| url | https://www.mdpi.com/2076-2615/14/24/3630 |
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