Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading
Tendons are unique connective tissues in the sense that their biological properties are largely determined by their tendon-specific stem cells, extracellular matrix (ECM) surrounding the stem cells, mechanical loading conditions placed on the tendon, and the complex interactions among them. This rev...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/3674647 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560599497703424 |
|---|---|
| author | Chuanxin Zhang Jun Zhu Yiqin Zhou Bhavani P. Thampatty James H-C. Wang |
| author_facet | Chuanxin Zhang Jun Zhu Yiqin Zhou Bhavani P. Thampatty James H-C. Wang |
| author_sort | Chuanxin Zhang |
| collection | DOAJ |
| description | Tendons are unique connective tissues in the sense that their biological properties are largely determined by their tendon-specific stem cells, extracellular matrix (ECM) surrounding the stem cells, mechanical loading conditions placed on the tendon, and the complex interactions among them. This review is aimed at providing an overview of recent advances in the identification and characterization of tendon stem/progenitor cells (TSPCs) and their interactions with ECM and mechanical loading. In addition, the effects of such interactions on the maintenance of tendon homeostasis and the initiation of tendon pathological conditions are discussed. Moreover, the challenges in further investigations of TSPC mechanobiology in vitro and in vivo are outlined. Finally, future research efforts are suggested, which include using specific gene knockout models and single-cell transcription profiling to enable a broad and deep understanding of the physiology and pathophysiology of tendons. |
| format | Article |
| id | doaj-art-5ecb1ea4c7e342ab875f59d25cf572c5 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-5ecb1ea4c7e342ab875f59d25cf572c52025-02-03T01:27:11ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/36746473674647Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical LoadingChuanxin Zhang0Jun Zhu1Yiqin Zhou2Bhavani P. Thampatty3James H-C. Wang4Joint Surgery and Sports Medicine Department, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaJoint Surgery and Sports Medicine Department, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaJoint Surgery and Sports Medicine Department, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, ChinaMechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USAMechanoBiology Laboratory, Departments of Orthopaedic Surgery, Bioengineering, and Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USATendons are unique connective tissues in the sense that their biological properties are largely determined by their tendon-specific stem cells, extracellular matrix (ECM) surrounding the stem cells, mechanical loading conditions placed on the tendon, and the complex interactions among them. This review is aimed at providing an overview of recent advances in the identification and characterization of tendon stem/progenitor cells (TSPCs) and their interactions with ECM and mechanical loading. In addition, the effects of such interactions on the maintenance of tendon homeostasis and the initiation of tendon pathological conditions are discussed. Moreover, the challenges in further investigations of TSPC mechanobiology in vitro and in vivo are outlined. Finally, future research efforts are suggested, which include using specific gene knockout models and single-cell transcription profiling to enable a broad and deep understanding of the physiology and pathophysiology of tendons.http://dx.doi.org/10.1155/2019/3674647 |
| spellingShingle | Chuanxin Zhang Jun Zhu Yiqin Zhou Bhavani P. Thampatty James H-C. Wang Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading Stem Cells International |
| title | Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading |
| title_full | Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading |
| title_fullStr | Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading |
| title_full_unstemmed | Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading |
| title_short | Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading |
| title_sort | tendon stem progenitor cells and their interactions with extracellular matrix and mechanical loading |
| url | http://dx.doi.org/10.1155/2019/3674647 |
| work_keys_str_mv | AT chuanxinzhang tendonstemprogenitorcellsandtheirinteractionswithextracellularmatrixandmechanicalloading AT junzhu tendonstemprogenitorcellsandtheirinteractionswithextracellularmatrixandmechanicalloading AT yiqinzhou tendonstemprogenitorcellsandtheirinteractionswithextracellularmatrixandmechanicalloading AT bhavanipthampatty tendonstemprogenitorcellsandtheirinteractionswithextracellularmatrixandmechanicalloading AT jameshcwang tendonstemprogenitorcellsandtheirinteractionswithextracellularmatrixandmechanicalloading |