Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture
Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain tran...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S105381192500031X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832087728021307392 |
|---|---|
| author | Yuanyuan Gao Ying Hu Jinlian Wang Chang Liu Hohjin Im Weipeng Jin Wenwei Zhu Wei Ge Guang Zhao Qiong Yao Pinchun Wang Manman Zhang Xin Niu Qinghua He Qiang Wang |
| author_facet | Yuanyuan Gao Ying Hu Jinlian Wang Chang Liu Hohjin Im Weipeng Jin Wenwei Zhu Wei Ge Guang Zhao Qiong Yao Pinchun Wang Manman Zhang Xin Niu Qinghua He Qiang Wang |
| author_sort | Yuanyuan Gao |
| collection | DOAJ |
| description | Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain transcriptomic and cellular characteristics, using Inter-Subject Representational Similarity Analysis (IS-RSA) and transcriptomic approaches. Behaviorally, we found that dispositional envy was associated with SVA. Structurally, SVA was positively correlated with increased morphological volumes in the orbitofrontal cortex (OFC) and bilateral cerebellum. Functionally, the dorsolateral prefrontal cortex (DLPFC), posterior cingulate cortex (PCC), cerebellum, and temporal pole (TP) exhibited heightened spontaneous activity, which was positively correlated with SVA severity. Transcriptomic and cellular analyses also showed specific genes linked to gray matter volume (GMV) associated with SVA, with predominant expression in excitatory and inhibitory neurons. These genes showed distinct spatiotemporal expression patterns in the cerebellum during adolescence. This study offers a comprehensive framework integrating structural, functional, and neurochemical evidence to highlight the neural-transcriptomic underpinnings of SVA symptoms in a non-clinical population. |
| format | Article |
| id | doaj-art-5ec10722cc1c41b7b0e931cb721ecff6 |
| institution | Kabale University |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-5ec10722cc1c41b7b0e931cb721ecff62025-02-06T05:11:07ZengElsevierNeuroImage1095-95722025-02-01307121029Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architectureYuanyuan Gao0Ying Hu1Jinlian Wang2Chang Liu3Hohjin Im4Weipeng Jin5Wenwei Zhu6Wei Ge7Guang Zhao8Qiong Yao9Pinchun Wang10Manman Zhang11Xin Niu12Qinghua He13Qiang Wang14Faculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaUnited StatesDepartment of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300060, ChinaSchool of Psychology, South China Normal University, Guangzhou 510631, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaSchool of Educational and Psychology Science, Hefei Normal University, Hefei 230601, ChinaCollege of Early Childhood Education, Tianjin Normal University, Tianjin 300387, China; Tianjin Normal School of Preschool Education, Tianjin 300387, ChinaFaculty of Psychology, Tianjin Normal University, Tianjin 300387, ChinaDepartment of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, United StatesFaculty of Psychology, MOE Key Lab of Cognition and Personality, Southwest University, Chongqing 400715, China; Corresponding authors.Faculty of Psychology, Tianjin Normal University, Tianjin 300387, China; State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing 100875, China; Institute of Mathematics and Interdisciplinary Sciences, Tianjin Normal University, Tianjin 300387, China; Corresponding authors.Short video addiction (SVA) has emerged as a growing behavioral and social issue, driven by the widespread use of digital platforms that provide highly engaging, personalized, and brief video content. We investigated the neuroanatomical and functional substrates of SVA symptoms, alongside brain transcriptomic and cellular characteristics, using Inter-Subject Representational Similarity Analysis (IS-RSA) and transcriptomic approaches. Behaviorally, we found that dispositional envy was associated with SVA. Structurally, SVA was positively correlated with increased morphological volumes in the orbitofrontal cortex (OFC) and bilateral cerebellum. Functionally, the dorsolateral prefrontal cortex (DLPFC), posterior cingulate cortex (PCC), cerebellum, and temporal pole (TP) exhibited heightened spontaneous activity, which was positively correlated with SVA severity. Transcriptomic and cellular analyses also showed specific genes linked to gray matter volume (GMV) associated with SVA, with predominant expression in excitatory and inhibitory neurons. These genes showed distinct spatiotemporal expression patterns in the cerebellum during adolescence. This study offers a comprehensive framework integrating structural, functional, and neurochemical evidence to highlight the neural-transcriptomic underpinnings of SVA symptoms in a non-clinical population.http://www.sciencedirect.com/science/article/pii/S105381192500031XShort video addictionGray matter volumeIS-RSATranscriptomic profile |
| spellingShingle | Yuanyuan Gao Ying Hu Jinlian Wang Chang Liu Hohjin Im Weipeng Jin Wenwei Zhu Wei Ge Guang Zhao Qiong Yao Pinchun Wang Manman Zhang Xin Niu Qinghua He Qiang Wang Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture NeuroImage Short video addiction Gray matter volume IS-RSA Transcriptomic profile |
| title | Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| title_full | Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| title_fullStr | Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| title_full_unstemmed | Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| title_short | Neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| title_sort | neuroanatomical and functional substrates of the short video addiction and its association with brain transcriptomic and cellular architecture |
| topic | Short video addiction Gray matter volume IS-RSA Transcriptomic profile |
| url | http://www.sciencedirect.com/science/article/pii/S105381192500031X |
| work_keys_str_mv | AT yuanyuangao neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT yinghu neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT jinlianwang neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT changliu neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT hohjinim neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT weipengjin neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT wenweizhu neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT weige neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT guangzhao neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT qiongyao neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT pinchunwang neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT manmanzhang neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT xinniu neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT qinghuahe neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture AT qiangwang neuroanatomicalandfunctionalsubstratesoftheshortvideoaddictionanditsassociationwithbraintranscriptomicandcellulararchitecture |