Interleukin-17: Potential Target for Chronic Wounds
Chronic wounds exhibit persistent inflammation with markedly delayed healing. The significant burden of chronic wounds, which are often resistant to standard therapy, prompts further research on novel therapies. Since the interleukin-17 family has been implicated as a group of proinflammatory cytoki...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/1297675 |
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| _version_ | 1832564263081738240 |
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| author | Yasmin Hadian Michelle D. Bagood Sara E. Dahle Apra Sood R. Rivkah Isseroff |
| author_facet | Yasmin Hadian Michelle D. Bagood Sara E. Dahle Apra Sood R. Rivkah Isseroff |
| author_sort | Yasmin Hadian |
| collection | DOAJ |
| description | Chronic wounds exhibit persistent inflammation with markedly delayed healing. The significant burden of chronic wounds, which are often resistant to standard therapy, prompts further research on novel therapies. Since the interleukin-17 family has been implicated as a group of proinflammatory cytokines in immune-mediated diseases in the gut and connective tissue, as well as inflammatory skin conditions, we consider here if it may contribute to the pathogenesis of chronic wounds. In this review, we discuss the interleukin-17 family’s signaling pathways and role in tissue repair. A PubMed review of the English literature on interleukin-17, wound healing, chronic wounds, and inflammatory skin conditions was conducted. Interleukin-17 family signaling is reviewed in the context of tissue repair, and preclinical and clinical studies examining its role in the skin and other organ systems are critically reviewed. The published work supports a pathologic role for interleukin-17 family members in chronic wounds, though this needs to be more conclusively proven. Clinical studies using monoclonal interleukin-17 antibodies to improve healing of chronic skin wounds have not yet been performed, and only a few studies have examined interleukin-17 family expression in chronic skin wounds. Furthermore, different interleukin-17 family members could be playing selective roles in the repair process. These studies suggest a therapeutic role for targeting interleukin-17A to promote wound healing; therefore, interleukin-17A may be a target worthy of pursuing in the near future. |
| format | Article |
| id | doaj-art-5eb600bdd20047fda064ffde755b6bd0 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5eb600bdd20047fda064ffde755b6bd02025-02-03T01:11:29ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/12976751297675Interleukin-17: Potential Target for Chronic WoundsYasmin Hadian0Michelle D. Bagood1Sara E. Dahle2Apra Sood3R. Rivkah Isseroff4Department of Dermatology, School of Medicine, University of California, Davis, CA, USADepartment of Dermatology, School of Medicine, University of California, Davis, CA, USADepartment of Dermatology, School of Medicine, University of California, Davis, CA, USADepartment of Dermatology, School of Medicine, University of California, Davis, CA, USADepartment of Dermatology, School of Medicine, University of California, Davis, CA, USAChronic wounds exhibit persistent inflammation with markedly delayed healing. The significant burden of chronic wounds, which are often resistant to standard therapy, prompts further research on novel therapies. Since the interleukin-17 family has been implicated as a group of proinflammatory cytokines in immune-mediated diseases in the gut and connective tissue, as well as inflammatory skin conditions, we consider here if it may contribute to the pathogenesis of chronic wounds. In this review, we discuss the interleukin-17 family’s signaling pathways and role in tissue repair. A PubMed review of the English literature on interleukin-17, wound healing, chronic wounds, and inflammatory skin conditions was conducted. Interleukin-17 family signaling is reviewed in the context of tissue repair, and preclinical and clinical studies examining its role in the skin and other organ systems are critically reviewed. The published work supports a pathologic role for interleukin-17 family members in chronic wounds, though this needs to be more conclusively proven. Clinical studies using monoclonal interleukin-17 antibodies to improve healing of chronic skin wounds have not yet been performed, and only a few studies have examined interleukin-17 family expression in chronic skin wounds. Furthermore, different interleukin-17 family members could be playing selective roles in the repair process. These studies suggest a therapeutic role for targeting interleukin-17A to promote wound healing; therefore, interleukin-17A may be a target worthy of pursuing in the near future.http://dx.doi.org/10.1155/2019/1297675 |
| spellingShingle | Yasmin Hadian Michelle D. Bagood Sara E. Dahle Apra Sood R. Rivkah Isseroff Interleukin-17: Potential Target for Chronic Wounds Mediators of Inflammation |
| title | Interleukin-17: Potential Target for Chronic Wounds |
| title_full | Interleukin-17: Potential Target for Chronic Wounds |
| title_fullStr | Interleukin-17: Potential Target for Chronic Wounds |
| title_full_unstemmed | Interleukin-17: Potential Target for Chronic Wounds |
| title_short | Interleukin-17: Potential Target for Chronic Wounds |
| title_sort | interleukin 17 potential target for chronic wounds |
| url | http://dx.doi.org/10.1155/2019/1297675 |
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