Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis
PGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the a...
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Frontiers Media S.A.
2025-01-01
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| Series: | Transplant International |
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| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13794/full |
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| author | Andrea Costamagna Eleonora Balzani Matteo Marro Erika Simonato Alessandro Burello Mauro Rinaldi Luca Brazzi Massimo Boffini Vito Fanelli |
| author_facet | Andrea Costamagna Eleonora Balzani Matteo Marro Erika Simonato Alessandro Burello Mauro Rinaldi Luca Brazzi Massimo Boffini Vito Fanelli |
| author_sort | Andrea Costamagna |
| collection | DOAJ |
| description | PGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the association between the levels of proinflammatory biomarkers during EVLP and PGD3 development within the firsts 72 h post-Ltx. Biomarkers were categorized by timing (1-hour, T0 and 4-hours, Tend from EVLPstart) and by their biological function (adhesion molecules, chemokines, cytokines, damage-associated-molecular-patterns, growth-factors, metabolites). We employed a four-level mixed-effects model with categorical predictors for biomarker groups to identify differences between patients with PGD3 and others. The single study and individual measurements were considered random intercepts. We included 8 studies (610 measurements at T0 and 884 at Tend). The pooled effect was 0.74 (p = 0.021) at T0, and 0.90 (p = 0.0015) at Tend. The four-level model indicated a large pooled correlation between developing PGD3 at 72 h post-Ltx and inflammatory biomarkers values, r = 0.62 (p = 0.009). Chemokine group showed the strongest association with the outcome (z-value = 1.26, p = 0.042). Pooled panels of inflammation markers, particularly chemokines, measured at T0 or at Tend, are associated with the development of PGD3 within the first 72 h after Ltx.Systematic Review Registrationhttps://osf.io/gkxzh/. |
| format | Article |
| id | doaj-art-5eadf82f35554ace8eaa7cb0c9a5f756 |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-5eadf82f35554ace8eaa7cb0c9a5f7562025-01-29T13:47:19ZengFrontiers Media S.A.Transplant International1432-22772025-01-013810.3389/ti.2025.1379413794Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-AnalysisAndrea Costamagna0Eleonora Balzani1Matteo Marro2Erika Simonato3Alessandro Burello4Mauro Rinaldi5Luca Brazzi6Massimo Boffini7Vito Fanelli8Department of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyCardiovascular and Thoracic Department, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, ItalyCardiovascular and Thoracic Department, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyDepartment of Surgical Sciences, University of Turin, Turin, ItalyPGD3 is the manifestation of ischemia-reperfusion injury which results from inflammation and cell death and is associated with poor outcome. This systematic-review and meta-analysis of non-randomized controlled trials on patients undergoing Ltx with reconditioned lungs via EVLP, aims to assess the association between the levels of proinflammatory biomarkers during EVLP and PGD3 development within the firsts 72 h post-Ltx. Biomarkers were categorized by timing (1-hour, T0 and 4-hours, Tend from EVLPstart) and by their biological function (adhesion molecules, chemokines, cytokines, damage-associated-molecular-patterns, growth-factors, metabolites). We employed a four-level mixed-effects model with categorical predictors for biomarker groups to identify differences between patients with PGD3 and others. The single study and individual measurements were considered random intercepts. We included 8 studies (610 measurements at T0 and 884 at Tend). The pooled effect was 0.74 (p = 0.021) at T0, and 0.90 (p = 0.0015) at Tend. The four-level model indicated a large pooled correlation between developing PGD3 at 72 h post-Ltx and inflammatory biomarkers values, r = 0.62 (p = 0.009). Chemokine group showed the strongest association with the outcome (z-value = 1.26, p = 0.042). Pooled panels of inflammation markers, particularly chemokines, measured at T0 or at Tend, are associated with the development of PGD3 within the first 72 h after Ltx.Systematic Review Registrationhttps://osf.io/gkxzh/.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13794/fullex vivo lung perfusionischemia-reperfusion injuryprimary graft dysfunctioninflammationbiomarkers |
| spellingShingle | Andrea Costamagna Eleonora Balzani Matteo Marro Erika Simonato Alessandro Burello Mauro Rinaldi Luca Brazzi Massimo Boffini Vito Fanelli Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis Transplant International ex vivo lung perfusion ischemia-reperfusion injury primary graft dysfunction inflammation biomarkers |
| title | Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis |
| title_full | Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis |
| title_fullStr | Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis |
| title_short | Association of Inflammatory Profile During Ex Vivo Lung Perfusion With High-Grade Primary Graft Dysfunction: A Systematic Review and Meta-Analysis |
| title_sort | association of inflammatory profile during ex vivo lung perfusion with high grade primary graft dysfunction a systematic review and meta analysis |
| topic | ex vivo lung perfusion ischemia-reperfusion injury primary graft dysfunction inflammation biomarkers |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.13794/full |
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