Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape

Intracellular HIV-1 Tat regulator induces epigenetic changes in the DNA methylation landscape

IntroductionThe HIV regulatory protein Tat enhances viral transcription and also modifies host gene expression, affecting cell functions like cell cycle and apoptosis. Residual expression of Tat protein is detected in blood and other tissues even under antiretroviral treatment. Cohort studies have...

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Main Authors: Andrea Rodríguez-Agustín, Rubén Ayala-Suárez, Francisco Díez-Fuertes, María José Maleno, Izar de Villasante, Angelika Merkel, Mayte Coiras, Víctor Casanova, José Alcamí, Núria Climent
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
HIV infection
Tat
epigenetics
DNA methylation
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532692/full
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