Infection of a β-galactosidase-deficient mouse strain with Theiler’s murine encephalomyelitis virus reveals limited immunological dysregulations in this lysosomal storage disease

Infection of a β-galactosidase-deficient mouse strain with Theiler’s murine encephalomyelitis virus reveals limited immunological dysregulations in this lysosomal storage disease

IntroductionA hallmark of many lysosomal storage diseases (LSD) is the alteration of immune responses, often starting before the onset of clinical disease. The present study aimed to investigate how GM1 gangliosidosis impacted the course of an acute central nervous system (CNS) virus infection befor...

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Bibliographic Details
Main Authors: Rouven Wannemacher, Felix Stegmann, Deborah Eikelberg, Melanie Bühler, Dandan Li, Sayali Kalidas Kohale, Thanaporn Asawapattanakul, Tim Ebbecke, Marie-Kristin Raulf, Wolfgang Baumgärtner, Bernd Lepenies, Ingo Gerhauser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
β-galactosidase deficiency
brain
GM1 gangliosidosis
microglia activation
T cell activation
Theiler’s murine encephalomyelitis virus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1467207/full
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