Research progress on energy metabolism regulation in stored platelets
In maintaining normal function and activation processes, glycolysis, lipid metabolism, and amino acid metabolism play key roles in the energy demand of platelets. In the resting state, platelets primarily rely on glycolysis and aerobic oxidation to generate energy. Upon activation, platelets prefere...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
|
| Series: | Zhongguo shuxue zazhi |
| Subjects: | |
| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.023&lang=en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585128908423168 |
|---|---|
| author | GAO Chengyan LOU Can LEI Hang CAI Xiaohong |
| author_facet | GAO Chengyan LOU Can LEI Hang CAI Xiaohong |
| author_sort | GAO Chengyan |
| collection | DOAJ |
| description | In maintaining normal function and activation processes, glycolysis, lipid metabolism, and amino acid metabolism play key roles in the energy demand of platelets. In the resting state, platelets primarily rely on glycolysis and aerobic oxidation to generate energy. Upon activation, platelets preferentially utilize glycolysis, as it can more rapidly provide the required ATP. In addition to glycolysis, platelets can also utilize glycogen and fatty acids as additional energy sources. The ATP provided by fatty acid oxidation is crucial for platelet activation. Additionally, during platelet storage, distinctive changes in energy metabolism occur. In the early stages of storage, platelets primarily rely on glycolysis and the pentose phosphate pathway (PPP) to generate energy. In the mid-storage phase, there is an increase in tricarboxylic acid cycle (TCA) metabolism. In the later stages of storage, cellular metabolism gradually declines. The regulation and flexibility of these metabolic pathways play a critical role in the survival and function of platelets in different states. |
| format | Article |
| id | doaj-art-5e70005e1e904a33bf6d900b95e5ad10 |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-5e70005e1e904a33bf6d900b95e5ad102025-01-27T01:46:12ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-0138113013510.13303/j.cjbt.issn.1004-549x.2025.01.0231004-549X(2025)1-0130-06Research progress on energy metabolism regulation in stored plateletsGAO Chengyan0LOU Can1LEI Hang2CAI Xiaohong3Department of Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Blood Transfusion, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaIn maintaining normal function and activation processes, glycolysis, lipid metabolism, and amino acid metabolism play key roles in the energy demand of platelets. In the resting state, platelets primarily rely on glycolysis and aerobic oxidation to generate energy. Upon activation, platelets preferentially utilize glycolysis, as it can more rapidly provide the required ATP. In addition to glycolysis, platelets can also utilize glycogen and fatty acids as additional energy sources. The ATP provided by fatty acid oxidation is crucial for platelet activation. Additionally, during platelet storage, distinctive changes in energy metabolism occur. In the early stages of storage, platelets primarily rely on glycolysis and the pentose phosphate pathway (PPP) to generate energy. In the mid-storage phase, there is an increase in tricarboxylic acid cycle (TCA) metabolism. In the later stages of storage, cellular metabolism gradually declines. The regulation and flexibility of these metabolic pathways play a critical role in the survival and function of platelets in different states.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.023&lang=enplateletsglucose metabolismlipid metabolismmetabolic regulation |
| spellingShingle | GAO Chengyan LOU Can LEI Hang CAI Xiaohong Research progress on energy metabolism regulation in stored platelets Zhongguo shuxue zazhi platelets glucose metabolism lipid metabolism metabolic regulation |
| title | Research progress on energy metabolism regulation in stored platelets |
| title_full | Research progress on energy metabolism regulation in stored platelets |
| title_fullStr | Research progress on energy metabolism regulation in stored platelets |
| title_full_unstemmed | Research progress on energy metabolism regulation in stored platelets |
| title_short | Research progress on energy metabolism regulation in stored platelets |
| title_sort | research progress on energy metabolism regulation in stored platelets |
| topic | platelets glucose metabolism lipid metabolism metabolic regulation |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.023&lang=en |
| work_keys_str_mv | AT gaochengyan researchprogressonenergymetabolismregulationinstoredplatelets AT loucan researchprogressonenergymetabolismregulationinstoredplatelets AT leihang researchprogressonenergymetabolismregulationinstoredplatelets AT caixiaohong researchprogressonenergymetabolismregulationinstoredplatelets |