Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study
Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is a common disease in older adults that causes extensive spinal ankylosis. However, its impact on quality of life (QOL) and locomotive syndrome (LS) remains unknown. Thus, we aimed to evaluate the DISH effect on QOL and LS in community-dwelli...
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2025-01-01
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| author | Kazuma Ohshima Hiroaki Nakashima Naoki Segi Sadayuki Ito Jun Ouchida Yasuhiko Takegami Shinya Ishizuka Ippei Yamauchi Yukiharu Hasegawa Kenta Murotani Shiro Imagama |
| author_facet | Kazuma Ohshima Hiroaki Nakashima Naoki Segi Sadayuki Ito Jun Ouchida Yasuhiko Takegami Shinya Ishizuka Ippei Yamauchi Yukiharu Hasegawa Kenta Murotani Shiro Imagama |
| author_sort | Kazuma Ohshima |
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| description | Abstract Diffuse idiopathic skeletal hyperostosis (DISH) is a common disease in older adults that causes extensive spinal ankylosis. However, its impact on quality of life (QOL) and locomotive syndrome (LS) remains unknown. Thus, we aimed to evaluate the DISH effect on QOL and LS in community-dwelling middle-aged and older adults. Data of community volunteers who attended a health checkup in 2018–2019 were assessed. A total of 455 subjects were included. Whole spine lateral radiographs were obtained to detect DISH according to the Resnik criteria. QOL was evaluated using SF-36 and EQ5D HUSV. LS was evaluated using the stand-up and two-step tests and GLFS-25. Multivariate regression analysis was performed, adjusting for sex, age, body mass index, and knee osteoarthritis. Additionally, a sex-stratified analysis was performed. DISH was detected in 83 (18.2%) participants. Multivariate analysis demonstrated that DISH was significantly associated with low EQ5D HSUV. Multivariate analysis in men demonstrated that DISH was associated with low PCS, low EQ5D HSUV, high LS stage. Multivariate analysis in women demonstrated that DISH was not associated with any QOL or LS. DISH may be associated with a poor QOL. Additionally, DISH is more common and produces a greater clinical impact in men than in women. |
| format | Article |
| id | doaj-art-5e65337417f24b6982191aba9692c75e |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Scientific Reports |
| spelling | doaj-art-5e65337417f24b6982191aba9692c75e2025-02-02T12:24:47ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-025-87878-9Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo studyKazuma Ohshima0Hiroaki Nakashima1Naoki Segi2Sadayuki Ito3Jun Ouchida4Yasuhiko Takegami5Shinya Ishizuka6Ippei Yamauchi7Yukiharu Hasegawa8Kenta Murotani9Shiro Imagama10Department of Orthopedic Surgery, Chutoen General Medical CenterDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineDepartment of Rehabilitation, Kansai University of Welfare SciencesBiostatistics Center, Kurume UniversityDepartment of Orthopedic Surgery, Nagoya University Graduate School of MedicineAbstract Diffuse idiopathic skeletal hyperostosis (DISH) is a common disease in older adults that causes extensive spinal ankylosis. However, its impact on quality of life (QOL) and locomotive syndrome (LS) remains unknown. Thus, we aimed to evaluate the DISH effect on QOL and LS in community-dwelling middle-aged and older adults. Data of community volunteers who attended a health checkup in 2018–2019 were assessed. A total of 455 subjects were included. Whole spine lateral radiographs were obtained to detect DISH according to the Resnik criteria. QOL was evaluated using SF-36 and EQ5D HUSV. LS was evaluated using the stand-up and two-step tests and GLFS-25. Multivariate regression analysis was performed, adjusting for sex, age, body mass index, and knee osteoarthritis. Additionally, a sex-stratified analysis was performed. DISH was detected in 83 (18.2%) participants. Multivariate analysis demonstrated that DISH was significantly associated with low EQ5D HSUV. Multivariate analysis in men demonstrated that DISH was associated with low PCS, low EQ5D HSUV, high LS stage. Multivariate analysis in women demonstrated that DISH was not associated with any QOL or LS. DISH may be associated with a poor QOL. Additionally, DISH is more common and produces a greater clinical impact in men than in women.https://doi.org/10.1038/s41598-025-87878-9Diffuse idiopathic skeletal hyperostosisYakumo studyLocomotive syndromeQuality of life |
| spellingShingle | Kazuma Ohshima Hiroaki Nakashima Naoki Segi Sadayuki Ito Jun Ouchida Yasuhiko Takegami Shinya Ishizuka Ippei Yamauchi Yukiharu Hasegawa Kenta Murotani Shiro Imagama Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study Scientific Reports Diffuse idiopathic skeletal hyperostosis Yakumo study Locomotive syndrome Quality of life |
| title | Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study |
| title_full | Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study |
| title_fullStr | Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study |
| title_full_unstemmed | Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study |
| title_short | Impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community-dwelling older adults: the Yakumo study |
| title_sort | impact of diffuse idiopathic skeletal hyperostosis on quality of life and locomotive syndrome in community dwelling older adults the yakumo study |
| topic | Diffuse idiopathic skeletal hyperostosis Yakumo study Locomotive syndrome Quality of life |
| url | https://doi.org/10.1038/s41598-025-87878-9 |
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