The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets
Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/849720 |
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| _version_ | 1832556674887450624 |
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| author | M. Isabel Palacios-Arreola Karen E. Nava-Castro Julieta I. Castro Eduardo García-Zepeda Julio C. Carrero Jorge Morales-Montor |
| author_facet | M. Isabel Palacios-Arreola Karen E. Nava-Castro Julieta I. Castro Eduardo García-Zepeda Julio C. Carrero Jorge Morales-Montor |
| author_sort | M. Isabel Palacios-Arreola |
| collection | DOAJ |
| description | Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects. Complicating the system further, these effects depend on the cellular milieu. In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance. Therefore, the chemokine system is becoming a target in cancer therapeutics. We review the emerging data and correlations between chemokines/chemokine receptors and breast cancer, their implications in cancer progression, and possible therapeutic strategies that exploit the chemokine system. |
| format | Article |
| id | doaj-art-5e561d45c28448eba6da45feb7798102 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-5e561d45c28448eba6da45feb77981022025-02-03T05:44:39ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/849720849720The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic TargetsM. Isabel Palacios-Arreola0Karen E. Nava-Castro1Julieta I. Castro2Eduardo García-Zepeda3Julio C. Carrero4Jorge Morales-Montor5Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, 04510 México, DF, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, 04510 México, DF, MexicoDirección de Enfermedades Crónicas y Cáncer, Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, 62115 Cuernavaca, MOR, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, 04510 México, DF, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, 04510 México, DF, MexicoDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, A.P. 70228, 04510 México, DF, MexicoChemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. The chemokine-chemokine receptor system comprises almost 50 chemokines and approximately 20 chemokine receptors; thus, there is no unique ligand for each receptor and the binding of different chemokines to the same receptor might have disparate effects. Complicating the system further, these effects depend on the cellular milieu. In cancer, although chemokines are associated primarily with the generation of a protumoral microenvironment and organ-directed metastasis, they also mediate other phenomena related to disease progression, such as angiogenesis and even chemoresistance. Therefore, the chemokine system is becoming a target in cancer therapeutics. We review the emerging data and correlations between chemokines/chemokine receptors and breast cancer, their implications in cancer progression, and possible therapeutic strategies that exploit the chemokine system.http://dx.doi.org/10.1155/2014/849720 |
| spellingShingle | M. Isabel Palacios-Arreola Karen E. Nava-Castro Julieta I. Castro Eduardo García-Zepeda Julio C. Carrero Jorge Morales-Montor The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets Journal of Immunology Research |
| title | The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets |
| title_full | The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets |
| title_fullStr | The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets |
| title_full_unstemmed | The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets |
| title_short | The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets |
| title_sort | role of chemokines in breast cancer pathology and its possible use as therapeutic targets |
| url | http://dx.doi.org/10.1155/2014/849720 |
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