Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer
Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/9328347 |
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| _version_ | 1832549854621990912 |
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| author | Yue Cao Xiaokun Gang Chenglin Sun Guixia Wang |
| author_facet | Yue Cao Xiaokun Gang Chenglin Sun Guixia Wang |
| author_sort | Yue Cao |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation. |
| format | Article |
| id | doaj-art-5e4c9b1010184b9fafa8157de3e3be16 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-5e4c9b1010184b9fafa8157de3e3be162025-02-03T06:08:25ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/93283479328347Mesenchymal Stem Cells Improve Healing of Diabetic Foot UlcerYue Cao0Xiaokun Gang1Chenglin Sun2Guixia Wang3Department of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Endocrinology and Metabolism, The First Hospital of Jilin University, Changchun 130021, ChinaMesenchymal stem cells (MSCs), an ideal cell source for regenerative therapy with no ethical issues, play an important role in diabetic foot ulcer (DFU). Growing evidence has demonstrated that MSCs transplantation can accelerate wound closure, ameliorate clinical parameters, and avoid amputation. In this review, we clarify the mechanism of preclinical studies, as well as safety and efficacy of clinical trials in the treatment of DFU. Bone marrow-derived mesenchymal stem cells (BM-MSCs), compared with MSCs derived from other tissues, may be a suitable cell type that can provide easy, effective, and cost-efficient transplantation to treat DFU and protect patients from amputation.http://dx.doi.org/10.1155/2017/9328347 |
| spellingShingle | Yue Cao Xiaokun Gang Chenglin Sun Guixia Wang Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer Journal of Diabetes Research |
| title | Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer |
| title_full | Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer |
| title_fullStr | Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer |
| title_full_unstemmed | Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer |
| title_short | Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer |
| title_sort | mesenchymal stem cells improve healing of diabetic foot ulcer |
| url | http://dx.doi.org/10.1155/2017/9328347 |
| work_keys_str_mv | AT yuecao mesenchymalstemcellsimprovehealingofdiabeticfootulcer AT xiaokungang mesenchymalstemcellsimprovehealingofdiabeticfootulcer AT chenglinsun mesenchymalstemcellsimprovehealingofdiabeticfootulcer AT guixiawang mesenchymalstemcellsimprovehealingofdiabeticfootulcer |