Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials
This paper reviews the effects of gut microbiota in regulating neurodegenerative diseases through controlling gut-brain axis. Specific microbial populations and their metabolites (short-chain fatty acids and tryptophan derivatives) regulate neuroinflammation, neurogenesis and neural barrier integrit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2024.1481390/full |
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| author | Kelly Jimin Park Yao Gao Yao Gao |
| author_facet | Kelly Jimin Park Yao Gao Yao Gao |
| author_sort | Kelly Jimin Park |
| collection | DOAJ |
| description | This paper reviews the effects of gut microbiota in regulating neurodegenerative diseases through controlling gut-brain axis. Specific microbial populations and their metabolites (short-chain fatty acids and tryptophan derivatives) regulate neuroinflammation, neurogenesis and neural barrier integrity. We then discuss ways by which these insights lead to possible interventions - probiotics, prebiotics, dietary modification, and fecal microbiota transplantation (FMT). We also describe what epidemiological and clinical studies have related certain microbiota profiles with the courses of neurodegenerative diseases and how these impact the establishment of microbiome-based diagnostics and individualized treatment options. We aim to guide microbial ecology research on this key link to neurodegenerative disorders and also to highlight collaborative approaches to manage neurological health by targeting microbiome-related factors. |
| format | Article |
| id | doaj-art-5e4c5ff3c39b48d3a23a5d6e6c18a3be |
| institution | OA Journals |
| issn | 1662-453X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-5e4c5ff3c39b48d3a23a5d6e6c18a3be2025-08-20T02:11:30ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2024-10-011810.3389/fnins.2024.14813901481390Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentialsKelly Jimin Park0Yao Gao1Yao Gao2Pomfret School, Pomfret, CT, United StatesVascular Biology Program, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Surgery, Harvard Medical School, Boston, MA, United StatesThis paper reviews the effects of gut microbiota in regulating neurodegenerative diseases through controlling gut-brain axis. Specific microbial populations and their metabolites (short-chain fatty acids and tryptophan derivatives) regulate neuroinflammation, neurogenesis and neural barrier integrity. We then discuss ways by which these insights lead to possible interventions - probiotics, prebiotics, dietary modification, and fecal microbiota transplantation (FMT). We also describe what epidemiological and clinical studies have related certain microbiota profiles with the courses of neurodegenerative diseases and how these impact the establishment of microbiome-based diagnostics and individualized treatment options. We aim to guide microbial ecology research on this key link to neurodegenerative disorders and also to highlight collaborative approaches to manage neurological health by targeting microbiome-related factors.https://www.frontiersin.org/articles/10.3389/fnins.2024.1481390/fullgut-brain axisneurodegenerationneuroinflammationgut microbiotametabolitesmechanisms |
| spellingShingle | Kelly Jimin Park Yao Gao Yao Gao Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials Frontiers in Neuroscience gut-brain axis neurodegeneration neuroinflammation gut microbiota metabolites mechanisms |
| title | Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials |
| title_full | Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials |
| title_fullStr | Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials |
| title_full_unstemmed | Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials |
| title_short | Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials |
| title_sort | gut brain axis and neurodegeneration mechanisms and therapeutic potentials |
| topic | gut-brain axis neurodegeneration neuroinflammation gut microbiota metabolites mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2024.1481390/full |
| work_keys_str_mv | AT kellyjiminpark gutbrainaxisandneurodegenerationmechanismsandtherapeuticpotentials AT yaogao gutbrainaxisandneurodegenerationmechanismsandtherapeuticpotentials AT yaogao gutbrainaxisandneurodegenerationmechanismsandtherapeuticpotentials |