Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays.

Use of allele-specific FAIRE to determine functional regulatory polymorphism using large-scale genotyping arrays.

Following the widespread use of genome-wide association studies (GWAS), focus is turning towards identification of causal variants rather than simply genetic markers of diseases and traits. As a step towards a high-throughput method to identify genome-wide, non-coding, functional regulatory variants...

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Main Authors: Andrew J P Smith, Philip Howard, Sonia Shah, Per Eriksson, Stefan Stender, Claudia Giambartolomei, Lasse Folkersen, Anne Tybjærg-Hansen, Meena Kumari, Jutta Palmen, Aroon D Hingorani, Philippa J Talmud, Steve E Humphries
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002908&type=printable
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