Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses
Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2013/486186 |
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| author | J. P. van Wijngaarden E. L. Doets A. Szczecińska O. W. Souverein M. E. Duffy C. Dullemeijer A. E. J. M. Cavelaars B. Pietruszka P. van't Veer A. Brzozowska R. A. M. Dhonukshe-Rutten C. P. G. M. de Groot |
| author_facet | J. P. van Wijngaarden E. L. Doets A. Szczecińska O. W. Souverein M. E. Duffy C. Dullemeijer A. E. J. M. Cavelaars B. Pietruszka P. van't Veer A. Brzozowska R. A. M. Dhonukshe-Rutten C. P. G. M. de Groot |
| author_sort | J. P. van Wijngaarden |
| collection | DOAJ |
| description | Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with fractures and bone mineral density (BMD).
Twenty-seven eligible cross-sectional (n=14) and prospective (n=13) observational studies and one RCT were identified. Meta-analysis on four prospective studies including 7475 people showed a modest decrease in fracture risk of 4% per 50 pmol/L increase in vitamin B12 levels, which was borderline significant (RR = 0.96, 95% CI = 0.92 to 1.00). Meta-analysis of eight studies including 11511
people showed an increased fracture risk of 4% per μmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07). We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association. Meta-analyses regarding vitamin B12, folate and homocysteine levels, and BMD were possible in female populations only and showed no associations. Results from studies regarding BMD that could not be included in the meta-analyses were not univocal. |
| format | Article |
| id | doaj-art-5e4712fc77d74782954f691af54be766 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-5e4712fc77d74782954f691af54be7662025-02-03T01:09:49ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322013-01-01201310.1155/2013/486186486186Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-AnalysesJ. P. van Wijngaarden0E. L. Doets1A. Szczecińska2O. W. Souverein3M. E. Duffy4C. Dullemeijer5A. E. J. M. Cavelaars6B. Pietruszka7P. van't Veer8A. Brzozowska9R. A. M. Dhonukshe-Rutten10C. P. G. M. de Groot11Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDepartment of Human Nutrition, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02 776 Warsaw, PolandDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsNorthern Ireland Centre for Food and Health (NICHE), University of Ulster, Coleraine BT52 1SA, UKDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDepartment of Human Nutrition, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02 776 Warsaw, PolandDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDepartment of Human Nutrition, Warsaw University of Life Sciences (SGGW), Nowoursynowska 159c, 02 776 Warsaw, PolandDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsDivision of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV Wageningen, The NetherlandsElevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes the available scientific evidence on associations of vitamin B12, folate, and homocysteine status with fractures and bone mineral density (BMD). Twenty-seven eligible cross-sectional (n=14) and prospective (n=13) observational studies and one RCT were identified. Meta-analysis on four prospective studies including 7475 people showed a modest decrease in fracture risk of 4% per 50 pmol/L increase in vitamin B12 levels, which was borderline significant (RR = 0.96, 95% CI = 0.92 to 1.00). Meta-analysis of eight studies including 11511 people showed an increased fracture risk of 4% per μmol/L increase in homocysteine concentration (RR = 1.04, 95% CI = 1.02 to 1.07). We could not draw a conclusion regarding folate levels and fracture risk, as too few studies investigated this association. Meta-analyses regarding vitamin B12, folate and homocysteine levels, and BMD were possible in female populations only and showed no associations. Results from studies regarding BMD that could not be included in the meta-analyses were not univocal.http://dx.doi.org/10.1155/2013/486186 |
| spellingShingle | J. P. van Wijngaarden E. L. Doets A. Szczecińska O. W. Souverein M. E. Duffy C. Dullemeijer A. E. J. M. Cavelaars B. Pietruszka P. van't Veer A. Brzozowska R. A. M. Dhonukshe-Rutten C. P. G. M. de Groot Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses Journal of Nutrition and Metabolism |
| title | Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses |
| title_full | Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses |
| title_fullStr | Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses |
| title_full_unstemmed | Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses |
| title_short | Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses |
| title_sort | vitamin b12 folate homocysteine and bone health in adults and elderly people a systematic review with meta analyses |
| url | http://dx.doi.org/10.1155/2013/486186 |
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