Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis
Objective: To evaluate the prevalence of growth hormone deficiency in patients who underwent cranial irradiation for brain tumors. Methods: Ovid Medline and Embase databases were used for review. Eligible studies were observational studies with brain tumor survivors who had growth hormone function e...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2025-07-01
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| Series: | Endocrine Oncology |
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| Online Access: | https://eo.bioscientifica.com/view/journals/eo/5/1/EO-25-0025.xml |
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| author | Tatiana Tselovalnikova Ben Ponvilawan Maria G Pavlova Cynthia Flanagan Sunpreet S Rakhra Betty M Drees |
| author_facet | Tatiana Tselovalnikova Ben Ponvilawan Maria G Pavlova Cynthia Flanagan Sunpreet S Rakhra Betty M Drees |
| author_sort | Tatiana Tselovalnikova |
| collection | DOAJ |
| description | Objective: To evaluate the prevalence of growth hormone deficiency in patients who underwent cranial irradiation for brain tumors. Methods: Ovid Medline and Embase databases were used for review. Eligible studies were observational studies with brain tumor survivors who had growth hormone function evaluated after treatment at age ≥18 years. Patient data on disease prevalence were pooled using the random-effect, generic inverse variance method. The presence of publication bias was determined by Egger’s test. Mann–Whitney U test, univariate and multivariate linear regression were used to determine the association and effect of covariates and growth hormone peak level. Results: After screening 3,355 relevant articles, seven studies were included. The pooled result showed that out of 3,489 patients who received radiation for brain tumors, regardless of age at the time of treatment, 50% developed growth hormone deficiency (95% CI 40–60%, I2 = 83%). Subgroup analysis based on the growth hormone peak level did not show differences between different cutoffs. Univariate linear regression using data from 27 patients showed that age at radiation and the time duration between radiation and the stimulation test (P = 0.03 and 0.002, respectively), but not radiation dose or sex, were significantly correlated with growth hormone peak level. After multivariate adjustment, only the time duration between radiation and the stimulation test was associated with decreased growth hormone peak level (P = 0.04). Conclusions: Half of brain tumor survivors develop growth hormone deficiency. A longer duration of follow-up is associated with higher risks of growth hormone deficiency. Lifelong follow-up is essential. |
| format | Article |
| id | doaj-art-5e35b1d710f94254b903766f385b65ba |
| institution | Kabale University |
| issn | 2634-4793 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Oncology |
| spelling | doaj-art-5e35b1d710f94254b903766f385b65ba2025-08-20T03:50:31ZengBioscientificaEndocrine Oncology2634-47932025-07-015110.1530/EO-25-00251Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysisTatiana Tselovalnikova0Ben Ponvilawan1Maria G Pavlova2Cynthia Flanagan3Sunpreet S Rakhra4Betty M Drees5University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USAUniversity of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USAFirst Moscow State Medical University (Sechenov University), Moscow, RussiaUniversity of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USASt. Luke’s Cancer Institute, Kansas City, Missouri, USAUniversity of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USAObjective: To evaluate the prevalence of growth hormone deficiency in patients who underwent cranial irradiation for brain tumors. Methods: Ovid Medline and Embase databases were used for review. Eligible studies were observational studies with brain tumor survivors who had growth hormone function evaluated after treatment at age ≥18 years. Patient data on disease prevalence were pooled using the random-effect, generic inverse variance method. The presence of publication bias was determined by Egger’s test. Mann–Whitney U test, univariate and multivariate linear regression were used to determine the association and effect of covariates and growth hormone peak level. Results: After screening 3,355 relevant articles, seven studies were included. The pooled result showed that out of 3,489 patients who received radiation for brain tumors, regardless of age at the time of treatment, 50% developed growth hormone deficiency (95% CI 40–60%, I2 = 83%). Subgroup analysis based on the growth hormone peak level did not show differences between different cutoffs. Univariate linear regression using data from 27 patients showed that age at radiation and the time duration between radiation and the stimulation test (P = 0.03 and 0.002, respectively), but not radiation dose or sex, were significantly correlated with growth hormone peak level. After multivariate adjustment, only the time duration between radiation and the stimulation test was associated with decreased growth hormone peak level (P = 0.04). Conclusions: Half of brain tumor survivors develop growth hormone deficiency. A longer duration of follow-up is associated with higher risks of growth hormone deficiency. Lifelong follow-up is essential.https://eo.bioscientifica.com/view/journals/eo/5/1/EO-25-0025.xmlgrowth hormone deficiencybrain tumorcranial irradiationgrowth hormone |
| spellingShingle | Tatiana Tselovalnikova Ben Ponvilawan Maria G Pavlova Cynthia Flanagan Sunpreet S Rakhra Betty M Drees Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis Endocrine Oncology growth hormone deficiency brain tumor cranial irradiation growth hormone |
| title | Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis |
| title_full | Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis |
| title_fullStr | Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis |
| title_short | Prevalence of growth hormone deficiency in brain tumor survivors: a systematic review and meta-analysis |
| title_sort | prevalence of growth hormone deficiency in brain tumor survivors a systematic review and meta analysis |
| topic | growth hormone deficiency brain tumor cranial irradiation growth hormone |
| url | https://eo.bioscientifica.com/view/journals/eo/5/1/EO-25-0025.xml |
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