Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate
The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance sol...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2014-12-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/acph-2014-0038 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569189760499712 |
|---|---|
| author | Srikanth Meka Venkata Wee Liang Vanitha A/P Hong Dharmalingham Senthil Rajan Sheshala Ravi Gorajana Adinarayana |
| author_facet | Srikanth Meka Venkata Wee Liang Vanitha A/P Hong Dharmalingham Senthil Rajan Sheshala Ravi Gorajana Adinarayana |
| author_sort | Srikanth Meka Venkata |
| collection | DOAJ |
| description | The objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected. |
| format | Article |
| id | doaj-art-5e21181eef54405cbf8885933938f72b |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2014-12-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-5e21181eef54405cbf8885933938f72b2025-02-02T23:02:22ZengSciendoActa Pharmaceutica1846-95582014-12-0164448549410.2478/acph-2014-0038acph-2014-0038Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphateSrikanth Meka Venkata0Wee Liang Vanitha A/P Hong1Dharmalingham Senthil Rajan2Sheshala Ravi3Gorajana Adinarayana4School of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000 Kuala Lumpur, MalaysiaThe objective of the study was to enhance the solubility of carvedilol phosphate and to formulate it into non-effervescent floating tablets using swellable polymers. Solid dispersions (SD) of carvedilol were prepared with hydrophilic carriers such as polyvinylpyrrolidone and poloxamer to enhance solubility. Non-effervescent floating tablets were prepared with a combination of optimized solid dispersions and release retarding polymers/swellable polymers such as xanthan gum and polyethylene oxide. Tablets were evaluated for physicochemical properties such as hardness, thickness and buoyancy. SD prepared with the drug to poloxamer ratio of 1:4 by melt granulation showed a higher dissolution rate than all other dispersions. Formulations containing 40 mg of polyethylene oxide (C-P40) and 50 mg xanthan gum (C-X50) were found to be best, with the drug retardation up to 12 hours. Optimized formulations were characterized using FTIR and DSC and no drug and excipient interactions were detected.https://doi.org/10.2478/acph-2014-0038carvedilol phosphatesolid dispersionnon-effervescentfloating tablets |
| spellingShingle | Srikanth Meka Venkata Wee Liang Vanitha A/P Hong Dharmalingham Senthil Rajan Sheshala Ravi Gorajana Adinarayana Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate Acta Pharmaceutica carvedilol phosphate solid dispersion non-effervescent floating tablets |
| title | Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate |
| title_full | Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate |
| title_fullStr | Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate |
| title_full_unstemmed | Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate |
| title_short | Preparation and in vitro characterization of non-effervescent floating drug delivery system of poorly soluble drug, carvedilol phosphate |
| title_sort | preparation and in vitro characterization of non effervescent floating drug delivery system of poorly soluble drug carvedilol phosphate |
| topic | carvedilol phosphate solid dispersion non-effervescent floating tablets |
| url | https://doi.org/10.2478/acph-2014-0038 |
| work_keys_str_mv | AT srikanthmekavenkata preparationandinvitrocharacterizationofnoneffervescentfloatingdrugdeliverysystemofpoorlysolubledrugcarvedilolphosphate AT weeliangvanithaaphong preparationandinvitrocharacterizationofnoneffervescentfloatingdrugdeliverysystemofpoorlysolubledrugcarvedilolphosphate AT dharmalinghamsenthilrajan preparationandinvitrocharacterizationofnoneffervescentfloatingdrugdeliverysystemofpoorlysolubledrugcarvedilolphosphate AT sheshalaravi preparationandinvitrocharacterizationofnoneffervescentfloatingdrugdeliverysystemofpoorlysolubledrugcarvedilolphosphate AT gorajanaadinarayana preparationandinvitrocharacterizationofnoneffervescentfloatingdrugdeliverysystemofpoorlysolubledrugcarvedilolphosphate |