Synaptic Structure and Function in the Mouse Somatosensory Cortex during Chronic Pain: In Vivo Two-Photon Imaging
Recent advances in two-photon microscopy and fluorescence labeling techniques have enabled us to directly see the structural and functional changes in neurons and glia, and even at synapses, in the brain of living animals. Long-term in vivo two-photon imaging studies have shown that some postsynapti...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2012/640259 |
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| author | Sun Kwang Kim Kei Eto Junichi Nabekura |
| author_facet | Sun Kwang Kim Kei Eto Junichi Nabekura |
| author_sort | Sun Kwang Kim |
| collection | DOAJ |
| description | Recent advances in two-photon microscopy and fluorescence labeling techniques have enabled us to directly see the structural and functional changes in neurons and glia, and even at synapses, in the brain of living animals. Long-term in vivo two-photon imaging studies have shown that some postsynaptic dendritic spines in the adult cortex are rapidly eliminated or newly generated, in response to altered sensory input or synaptic activity, resulting in experience/activity-dependent rewiring of neuronal circuits. In vivo Ca2+ imaging studies have revealed the distinct, input-specific response patterns of excitatory neurons in the brain. These updated in vivo approaches are just beginning to be used for the study of pathophysiological mechanisms of chronic diseases. In this paper, we introduce recent in vivo two-photon imaging studies demonstrating how plastic changes in synaptic structure and function of the mouse somatosensory cortex, following peripheral injury, contribute to chronic pain conditions, like neuropathic and inflammatory pain. |
| format | Article |
| id | doaj-art-5e15c44a51a044b69d54316d8c1db57d |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5e15c44a51a044b69d54316d8c1db57d2025-02-03T01:25:03ZengWileyNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/640259640259Synaptic Structure and Function in the Mouse Somatosensory Cortex during Chronic Pain: In Vivo Two-Photon ImagingSun Kwang Kim0Kei Eto1Junichi Nabekura2Division of Homeostatic Development, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, JapanDivision of Homeostatic Development, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, JapanDivision of Homeostatic Development, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, JapanRecent advances in two-photon microscopy and fluorescence labeling techniques have enabled us to directly see the structural and functional changes in neurons and glia, and even at synapses, in the brain of living animals. Long-term in vivo two-photon imaging studies have shown that some postsynaptic dendritic spines in the adult cortex are rapidly eliminated or newly generated, in response to altered sensory input or synaptic activity, resulting in experience/activity-dependent rewiring of neuronal circuits. In vivo Ca2+ imaging studies have revealed the distinct, input-specific response patterns of excitatory neurons in the brain. These updated in vivo approaches are just beginning to be used for the study of pathophysiological mechanisms of chronic diseases. In this paper, we introduce recent in vivo two-photon imaging studies demonstrating how plastic changes in synaptic structure and function of the mouse somatosensory cortex, following peripheral injury, contribute to chronic pain conditions, like neuropathic and inflammatory pain.http://dx.doi.org/10.1155/2012/640259 |
| spellingShingle | Sun Kwang Kim Kei Eto Junichi Nabekura Synaptic Structure and Function in the Mouse Somatosensory Cortex during Chronic Pain: In Vivo Two-Photon Imaging Neural Plasticity |
| title | Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging |
| title_full | Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging |
| title_fullStr | Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging |
| title_full_unstemmed | Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging |
| title_short | Synaptic Structure and Function in the Mouse Somatosensory Cortex
during Chronic Pain: In Vivo Two-Photon Imaging |
| title_sort | synaptic structure and function in the mouse somatosensory cortex during chronic pain in vivo two photon imaging |
| url | http://dx.doi.org/10.1155/2012/640259 |
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