Licoisoflavone B and glabridin from Glycyrrhiza glabra as potent nucleoprotein antagonists of Lassa virus: insights from molecular docking, dynamics simulation, PCA, and DFT studies

Licoisoflavone B and glabridin from Glycyrrhiza glabra as potent nucleoprotein antagonists of Lassa virus: insights from molecular docking, dynamics simulation, PCA, and DFT studies

Lassa virus causes a severe hemorrhagic disease referred to as Lassa fever. It exhibits a significant mortality rate among people in West and Central Africa. Currently, there is no vaccine available, and ribavirin is the sole treatment option with significant limitations. Given the lack of an effect...

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Bibliographic Details
Main Authors: Sk. Faisal Ahmed, Md. Masudur Rahman Munna, Md. Hossain Ahmed, Md. Mostafizur Rahman, Minhajul Islam, Esha Mony Bristy
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Lassa fever
Viral replication
ADMET
Molecular dynamics simulation
Principal component analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1687157X25000885
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