Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy
Abstract Objectives To determine the prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia (EIN) post-hysterectomy and identify pre-hysterectomy risk factors predictive of occult carcinoma. Methods This retrospective study included patients diagnosed with...
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BMC
2025-01-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | https://doi.org/10.1186/s12957-025-03677-6 |
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| author | Waraphon Thongsang Sompop Kuljarusnont Suchanan Hanamornroongruang Irene Ruengkhachorn |
| author_facet | Waraphon Thongsang Sompop Kuljarusnont Suchanan Hanamornroongruang Irene Ruengkhachorn |
| author_sort | Waraphon Thongsang |
| collection | DOAJ |
| description | Abstract Objectives To determine the prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia (EIN) post-hysterectomy and identify pre-hysterectomy risk factors predictive of occult carcinoma. Methods This retrospective study included patients diagnosed with EIN between 2007 and 2021 who underwent hysterectomy as primary treatment. An expert gynecologic pathologist reviewed pathological slides. Data collected from medical records included demographic and gynecologic information, sonographic findings, and surgical and pathological outcomes. The prevalence of occult endometrial carcinoma was calculated. Descriptive statistics evaluated carcinoma incidence, and logistic regression analysis identified independent risk factors. Results A total of 113 patients were evaluated. The median time to hysterectomy was 9.1 weeks (range 5.8–12.8 weeks). Post-hysterectomy, 36 patients (31.8%) were diagnosed with endometrial carcinoma, all endometrioid type. Of these, 88.9% were stage I per the International Federation of Gynecology and Obstetrics classification system, and 11.1% were at high risk for nodal metastasis. Predictive factors for occult carcinoma included the intraoperative gross lesion size (2 cm or larger and less than 2 cm) and endometrial aspiration. Adjusted odds ratios were 6.723 (95% CI 2.338 to 19.333) for lesions 2 cm or larger, 3.381 (95% CI 1.128 to 10.132) for lesions less than 2 cm, and 2.752 (95% CI 1.092 to 6.936) for endometrial aspiration. Conclusions Occult endometrial carcinoma was identified in 31.8% of patients with a pre-hysterectomy EIN diagnosis. The significant predictors were endometrial aspiration and the presence of a gross lesion during surgery. |
| format | Article |
| id | doaj-art-5e002dcb0ad04202bf0885f8fe2aedea |
| institution | Kabale University |
| issn | 1477-7819 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj-art-5e002dcb0ad04202bf0885f8fe2aedea2025-01-26T12:36:36ZengBMCWorld Journal of Surgical Oncology1477-78192025-01-012311710.1186/s12957-025-03677-6Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomyWaraphon Thongsang0Sompop Kuljarusnont1Suchanan Hanamornroongruang2Irene Ruengkhachorn3Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityDepartment of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol UniversityAbstract Objectives To determine the prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia (EIN) post-hysterectomy and identify pre-hysterectomy risk factors predictive of occult carcinoma. Methods This retrospective study included patients diagnosed with EIN between 2007 and 2021 who underwent hysterectomy as primary treatment. An expert gynecologic pathologist reviewed pathological slides. Data collected from medical records included demographic and gynecologic information, sonographic findings, and surgical and pathological outcomes. The prevalence of occult endometrial carcinoma was calculated. Descriptive statistics evaluated carcinoma incidence, and logistic regression analysis identified independent risk factors. Results A total of 113 patients were evaluated. The median time to hysterectomy was 9.1 weeks (range 5.8–12.8 weeks). Post-hysterectomy, 36 patients (31.8%) were diagnosed with endometrial carcinoma, all endometrioid type. Of these, 88.9% were stage I per the International Federation of Gynecology and Obstetrics classification system, and 11.1% were at high risk for nodal metastasis. Predictive factors for occult carcinoma included the intraoperative gross lesion size (2 cm or larger and less than 2 cm) and endometrial aspiration. Adjusted odds ratios were 6.723 (95% CI 2.338 to 19.333) for lesions 2 cm or larger, 3.381 (95% CI 1.128 to 10.132) for lesions less than 2 cm, and 2.752 (95% CI 1.092 to 6.936) for endometrial aspiration. Conclusions Occult endometrial carcinoma was identified in 31.8% of patients with a pre-hysterectomy EIN diagnosis. The significant predictors were endometrial aspiration and the presence of a gross lesion during surgery.https://doi.org/10.1186/s12957-025-03677-6CancerEINEndometrial intraepithelial neoplasiaEndometriumOccult endometrial carcinoma |
| spellingShingle | Waraphon Thongsang Sompop Kuljarusnont Suchanan Hanamornroongruang Irene Ruengkhachorn Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy World Journal of Surgical Oncology Cancer EIN Endometrial intraepithelial neoplasia Endometrium Occult endometrial carcinoma |
| title | Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| title_full | Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| title_fullStr | Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| title_full_unstemmed | Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| title_short | Prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| title_sort | prevalence of occult endometrial carcinoma in patients with endometrial intraepithelial neoplasia who underwent hysterectomy |
| topic | Cancer EIN Endometrial intraepithelial neoplasia Endometrium Occult endometrial carcinoma |
| url | https://doi.org/10.1186/s12957-025-03677-6 |
| work_keys_str_mv | AT waraphonthongsang prevalenceofoccultendometrialcarcinomainpatientswithendometrialintraepithelialneoplasiawhounderwenthysterectomy AT sompopkuljarusnont prevalenceofoccultendometrialcarcinomainpatientswithendometrialintraepithelialneoplasiawhounderwenthysterectomy AT suchananhanamornroongruang prevalenceofoccultendometrialcarcinomainpatientswithendometrialintraepithelialneoplasiawhounderwenthysterectomy AT ireneruengkhachorn prevalenceofoccultendometrialcarcinomainpatientswithendometrialintraepithelialneoplasiawhounderwenthysterectomy |