Case Report: CAR-T therapy for primary cerebellar ALK-negative anaplastic large cell lymphoma

Case Report: CAR-T therapy for primary cerebellar ALK-negative anaplastic large cell lymphoma

Primary central nervous system (CNS) T-cell lymphomas, such as anaplastic large-cell lymphoma (ALCL) with anaplastic lymphoma kinase (ALK) negativity, are relatively rare and aggressive. Despite the administration of high-dose methotrexate (HD-MTX) therapy, the prognosis remains pessimistic. We repo...

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Bibliographic Details
Main Authors: Zhongqing Zou, Sihan Lai, Hai Yi, Qian Zhang, Hao Yao, Hui Yang, Ling Zhang, Alex H. Chang, Yi Su, Jin Rao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
primary central nervous system lymphoma (PCNSL)
T-cell lymphoma
cerebellar
ALK
ALCL
CAR-T
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1570214/full
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