STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells

STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells

Abstract Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORAI1. We here identify patients with a novel mutation...

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Bibliographic Details
Main Authors: Sascha Kahlfuss, Ulrike Kaufmann, Axel R Concepcion, Lucile Noyer, Dimitrius Raphael, Martin Vaeth, Jun Yang, Priya Pancholi, Mate Maus, James Muller, Lina Kozhaya, Alireza Khodadadi‐Jamayran, Zhengxi Sun, Patrick Shaw, Derya Unutmaz, Peter B Stathopulos, Cori Feist, Scott B Cameron, Stuart E Turvey, Stefan Feske
Format: Article
Language:English
Published: Springer Nature 2020-07-01
Series:EMBO Molecular Medicine
Subjects:
Ca2+ channel
Candida albicans
immunodeficiency
STIM1
Th17 cells
Online Access:https://doi.org/10.15252/emmm.201911592
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