Total immunoglobulin E levels in induced sputum reflect asthma control status
Abstract Background Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated. Methods Patients with asthma were classified as well controlled, partly controlled, and uncon...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.70021 |
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| author | Wenhui Chen Xiaofang Liu Xiujuan Yao Yanghe Hao Zhuo Zhou Chengshuo Wang Ming Wang Luo Zhang |
| author_facet | Wenhui Chen Xiaofang Liu Xiujuan Yao Yanghe Hao Zhuo Zhou Chengshuo Wang Ming Wang Luo Zhang |
| author_sort | Wenhui Chen |
| collection | DOAJ |
| description | Abstract Background Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated. Methods Patients with asthma were classified as well controlled, partly controlled, and uncontrolled asthma (UCA) according to Global Initiative for Asthma 2022 guidelines. Lung function and fractional exhaled nitric oxide (FeNO) were evaluated. Induced sputum was collected and total IgE and Phadiatop (IgE to common inhalant allergens) measurements were performed. General clinical characteristics and pulmonary inflammation indicators were analyzed between the three groups of asthmatic patients. Univariate and multifactor ordinal logistic regression were used to model the relationship between pulmonary inflammation indicators and asthma control status. The ability of sputum total IgE in identifying different levels of asthma control was assessed by receiver operating characteristic curve (ROC). Results Patients with UCA had worse lung function and airway inflammation as indicated by lower levels of forced expiratory volume in 1s (FEV1)%pred, FEV1/FVC, MEF75%pred, MEF50%pred and MEF25%pred, and higher levels of FeNO and sputum eosinophil% compared with the WCA group. In addition, higher levels of total sputum IgE and Phadiatop were found in patients with UCA than in patients with WCA and PCA. Univariate and multifactor ordinal logistic regression analysis indicated that sputum total IgE was the unique significant risk factor for poor asthma control (adjusted odds ratio = 6.25; 95% CI, 1.07–36.55; p < 0.05) among pulmonary inflammation indicators including different indices of pulmonary function test, sputum IgE and FeNO. Sputum total IgE levels showed a significant correlation with asthma control scores (r = 0.53, p < 0.001). Moreover, ROC analysis showed that the predictive value of sputum total IgE for patients with UCA was 0.82 (95% CI, 0.74–0.9). Conclusion Sputum total IgE reflects levels of asthma control, and can be used as an indicator of UCA. |
| format | Article |
| id | doaj-art-5de6dcceb4f34b209e3c68bcfc788c19 |
| institution | Kabale University |
| issn | 2045-7022 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj-art-5de6dcceb4f34b209e3c68bcfc788c192025-01-29T05:38:32ZengWileyClinical and Translational Allergy2045-70222025-01-01151n/an/a10.1002/clt2.70021Total immunoglobulin E levels in induced sputum reflect asthma control statusWenhui Chen0Xiaofang Liu1Xiujuan Yao2Yanghe Hao3Zhuo Zhou4Chengshuo Wang5Ming Wang6Luo Zhang7Department of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Respiratory and Critical Care Medicine Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Respiratory and Critical Care Medicine Beijing Tongren Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaDepartment of Otolaryngology Head and Neck Surgery Beijing TongRen Hospital Capital Medical University Beijing ChinaAbstract Background Most patients with severe asthma are sensitized to at least one allergen. Whether local immunoglobulin E (IgE) in induced sputum reflects asthma control status has not been investigated. Methods Patients with asthma were classified as well controlled, partly controlled, and uncontrolled asthma (UCA) according to Global Initiative for Asthma 2022 guidelines. Lung function and fractional exhaled nitric oxide (FeNO) were evaluated. Induced sputum was collected and total IgE and Phadiatop (IgE to common inhalant allergens) measurements were performed. General clinical characteristics and pulmonary inflammation indicators were analyzed between the three groups of asthmatic patients. Univariate and multifactor ordinal logistic regression were used to model the relationship between pulmonary inflammation indicators and asthma control status. The ability of sputum total IgE in identifying different levels of asthma control was assessed by receiver operating characteristic curve (ROC). Results Patients with UCA had worse lung function and airway inflammation as indicated by lower levels of forced expiratory volume in 1s (FEV1)%pred, FEV1/FVC, MEF75%pred, MEF50%pred and MEF25%pred, and higher levels of FeNO and sputum eosinophil% compared with the WCA group. In addition, higher levels of total sputum IgE and Phadiatop were found in patients with UCA than in patients with WCA and PCA. Univariate and multifactor ordinal logistic regression analysis indicated that sputum total IgE was the unique significant risk factor for poor asthma control (adjusted odds ratio = 6.25; 95% CI, 1.07–36.55; p < 0.05) among pulmonary inflammation indicators including different indices of pulmonary function test, sputum IgE and FeNO. Sputum total IgE levels showed a significant correlation with asthma control scores (r = 0.53, p < 0.001). Moreover, ROC analysis showed that the predictive value of sputum total IgE for patients with UCA was 0.82 (95% CI, 0.74–0.9). Conclusion Sputum total IgE reflects levels of asthma control, and can be used as an indicator of UCA.https://doi.org/10.1002/clt2.70021asthma controlimmunoglobulin Einduced sputumuncontrolled asthma |
| spellingShingle | Wenhui Chen Xiaofang Liu Xiujuan Yao Yanghe Hao Zhuo Zhou Chengshuo Wang Ming Wang Luo Zhang Total immunoglobulin E levels in induced sputum reflect asthma control status Clinical and Translational Allergy asthma control immunoglobulin E induced sputum uncontrolled asthma |
| title | Total immunoglobulin E levels in induced sputum reflect asthma control status |
| title_full | Total immunoglobulin E levels in induced sputum reflect asthma control status |
| title_fullStr | Total immunoglobulin E levels in induced sputum reflect asthma control status |
| title_full_unstemmed | Total immunoglobulin E levels in induced sputum reflect asthma control status |
| title_short | Total immunoglobulin E levels in induced sputum reflect asthma control status |
| title_sort | total immunoglobulin e levels in induced sputum reflect asthma control status |
| topic | asthma control immunoglobulin E induced sputum uncontrolled asthma |
| url | https://doi.org/10.1002/clt2.70021 |
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