Long-Term Recording of LTP in Cultured Hippocampal Slices
Long-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was com...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2002-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/NP.2002.249 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548119934402560 |
|---|---|
| author | Ken Shimono Michel Baudry Lam Ho Makoto Taketani Gary Lynch |
| author_facet | Ken Shimono Michel Baudry Lam Ho Makoto Taketani Gary Lynch |
| author_sort | Ken Shimono |
| collection | DOAJ |
| description | Long-term potentiation (LTP) was elicited
by high frequency stimulation in hippocampal
slices cultured on multi-electrode arrays. LTP
lasting more than 1 h was recorded in 75% of
slices, and a significant number of slices
exhibited a non-decaying LTP that lasted more
than 48 h. LTP induction was completely and
reversibly blocked by an antagonist of the
NMDA receptor, APV. Our results suggest the
possibility of using chronic recording in
hippocampal slices cultured on multi-electrode
arrays to study the mechanisms underlying
LTP maintenance and stabilization. |
| format | Article |
| id | doaj-art-5ddd7299f69b4c39a70fa74d7af3f109 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-5ddd7299f69b4c39a70fa74d7af3f1092025-02-03T06:42:09ZengWileyNeural Plasticity2090-59041687-54432002-01-019424925410.1155/NP.2002.249Long-Term Recording of LTP in Cultured Hippocampal SlicesKen Shimono0Michel Baudry1Lam Ho2Makoto Taketani3Gary Lynch4Tensor Biosciences, Irvine 92612, CA, USADept. Psychiatry and Human Behavior, University of California, 101 Theory Dr., suite 250, Irvine 92697, CA, USATensor Biosciences, Irvine 92612, CA, USATensor Biosciences, Irvine 92612, CA, USADept. Psychiatry and Human Behavior, University of California, 101 Theory Dr., suite 250, Irvine 92697, CA, USALong-term potentiation (LTP) was elicited by high frequency stimulation in hippocampal slices cultured on multi-electrode arrays. LTP lasting more than 1 h was recorded in 75% of slices, and a significant number of slices exhibited a non-decaying LTP that lasted more than 48 h. LTP induction was completely and reversibly blocked by an antagonist of the NMDA receptor, APV. Our results suggest the possibility of using chronic recording in hippocampal slices cultured on multi-electrode arrays to study the mechanisms underlying LTP maintenance and stabilization.http://dx.doi.org/10.1155/NP.2002.249 |
| spellingShingle | Ken Shimono Michel Baudry Lam Ho Makoto Taketani Gary Lynch Long-Term Recording of LTP in Cultured Hippocampal Slices Neural Plasticity |
| title | Long-Term Recording of LTP in Cultured Hippocampal Slices |
| title_full | Long-Term Recording of LTP in Cultured Hippocampal Slices |
| title_fullStr | Long-Term Recording of LTP in Cultured Hippocampal Slices |
| title_full_unstemmed | Long-Term Recording of LTP in Cultured Hippocampal Slices |
| title_short | Long-Term Recording of LTP in Cultured Hippocampal Slices |
| title_sort | long term recording of ltp in cultured hippocampal slices |
| url | http://dx.doi.org/10.1155/NP.2002.249 |
| work_keys_str_mv | AT kenshimono longtermrecordingofltpinculturedhippocampalslices AT michelbaudry longtermrecordingofltpinculturedhippocampalslices AT lamho longtermrecordingofltpinculturedhippocampalslices AT makototaketani longtermrecordingofltpinculturedhippocampalslices AT garylynch longtermrecordingofltpinculturedhippocampalslices |