Purine metabolism-associated key genes depict the immune landscape in gout patients
Abstract Gout is the most common form of inflammatory arthritis that affects approximately 1% to 6.8% of the global population. Less than half of gout patients received urate-lowering therapy and compliance to the therapy, along with the climbing prevalence, adds a tight burden to public health, not...
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| Format: | Article |
| Language: | English |
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Springer
2025-02-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-01956-y |
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| author | Lin-na Li Hao Wang Lu-shan Xiao Wei-nan Lai |
| author_facet | Lin-na Li Hao Wang Lu-shan Xiao Wei-nan Lai |
| author_sort | Lin-na Li |
| collection | DOAJ |
| description | Abstract Gout is the most common form of inflammatory arthritis that affects approximately 1% to 6.8% of the global population. Less than half of gout patients received urate-lowering therapy and compliance to the therapy, along with the climbing prevalence, adds a tight burden to public health, not to mention the potential tumor risk incurred by persistent inflammation in the patients. Thus, the study aimed to explore the links between gout, immune responses, and tumor development in terms of genetic alterations. Using RNA-seq data of peripheral blood mononuclear cells (PBMCs) from gout patients, we screened the differentially expressed genes (DEGs) of gout patients and found that they were closely involved in purine metabolism. We then focused on purine metabolism-related DEGs, and machine learning algorithms validated that these genes can help to discriminate gout from healthy conditions. ssGSEA revealed that these DEGs were significantly linked to immune reprogramming concerning fluctuation in the proportion and activity of various immunocytes. Most importantly, they were also partially dysregulated in a wide range of malignancies and exerted a notable influence on the survival of tumor patients, especially LIHC (Liver hepatocellular carcinoma). Therefore, our study made an urgent appeal to due attention to the underlying crosstalk among purine metabolism, immune responses, and tumor development in gout patients. |
| format | Article |
| id | doaj-art-5dcf83f245354fe7a2d287cff477fbc0 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-5dcf83f245354fe7a2d287cff477fbc02025-08-20T02:15:17ZengSpringerDiscover Oncology2730-60112025-02-0116111910.1007/s12672-025-01956-yPurine metabolism-associated key genes depict the immune landscape in gout patientsLin-na Li0Hao Wang1Lu-shan Xiao2Wei-nan Lai3Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical UniversityNanfang Hospital, Southern Medical UniversityDepartment of Infectious Diseases, Nanfang Hospital, Southern Medical UniversityDepartment of Rheumatology and Immunology, Nanfang Hospital, Southern Medical UniversityAbstract Gout is the most common form of inflammatory arthritis that affects approximately 1% to 6.8% of the global population. Less than half of gout patients received urate-lowering therapy and compliance to the therapy, along with the climbing prevalence, adds a tight burden to public health, not to mention the potential tumor risk incurred by persistent inflammation in the patients. Thus, the study aimed to explore the links between gout, immune responses, and tumor development in terms of genetic alterations. Using RNA-seq data of peripheral blood mononuclear cells (PBMCs) from gout patients, we screened the differentially expressed genes (DEGs) of gout patients and found that they were closely involved in purine metabolism. We then focused on purine metabolism-related DEGs, and machine learning algorithms validated that these genes can help to discriminate gout from healthy conditions. ssGSEA revealed that these DEGs were significantly linked to immune reprogramming concerning fluctuation in the proportion and activity of various immunocytes. Most importantly, they were also partially dysregulated in a wide range of malignancies and exerted a notable influence on the survival of tumor patients, especially LIHC (Liver hepatocellular carcinoma). Therefore, our study made an urgent appeal to due attention to the underlying crosstalk among purine metabolism, immune responses, and tumor development in gout patients.https://doi.org/10.1007/s12672-025-01956-yGoutMetabolic diseasesCellular immunitiesTumors |
| spellingShingle | Lin-na Li Hao Wang Lu-shan Xiao Wei-nan Lai Purine metabolism-associated key genes depict the immune landscape in gout patients Discover Oncology Gout Metabolic diseases Cellular immunities Tumors |
| title | Purine metabolism-associated key genes depict the immune landscape in gout patients |
| title_full | Purine metabolism-associated key genes depict the immune landscape in gout patients |
| title_fullStr | Purine metabolism-associated key genes depict the immune landscape in gout patients |
| title_full_unstemmed | Purine metabolism-associated key genes depict the immune landscape in gout patients |
| title_short | Purine metabolism-associated key genes depict the immune landscape in gout patients |
| title_sort | purine metabolism associated key genes depict the immune landscape in gout patients |
| topic | Gout Metabolic diseases Cellular immunities Tumors |
| url | https://doi.org/10.1007/s12672-025-01956-y |
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