Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease
The octapeptide long acting somatostatin analogue, SMS 201-995 promotes intestinal fluid and electrolyte absorption and inhibits anion secretion. It is more potent than native somatostatin and does not exhibit tachyphylaxsis. SMS 201-995 was used to treat two patients with severe diarrhea associated...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1989-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1989/525713 |
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| _version_ | 1832560247032512512 |
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| author | Richard N. Fedorak Richard W. Sherbaniuk |
| author_facet | Richard N. Fedorak Richard W. Sherbaniuk |
| author_sort | Richard N. Fedorak |
| collection | DOAJ |
| description | The octapeptide long acting somatostatin analogue, SMS 201-995
promotes intestinal fluid and electrolyte absorption and inhibits anion secretion.
It is more potent than native somatostatin and does not exhibit tachyphylaxsis.
SMS 201-995 was used to treat two patients with severe diarrhea associated with
Crohn’s disease after other treatments had failed. The volume and frequency of
ileostomy output in one patient and stool output in the other did not respond to
therapy with SMS 201-995. ln fact, diarrhea appeared to increase in both patients
while on treatment. |
| format | Article |
| id | doaj-art-5dc7093e9f25448fbbb4fd60ca358563 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1989-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-5dc7093e9f25448fbbb4fd60ca3585632025-02-03T01:28:01ZengWileyCanadian Journal of Gastroenterology0835-79001989-01-0132535710.1155/1989/525713Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel DiseaseRichard N. Fedorak0Richard W. Sherbaniuk1Department of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaDepartment of Medicine, Division of Gastroenterology, University of Alberta, Edmonton, Alberta, CanadaThe octapeptide long acting somatostatin analogue, SMS 201-995 promotes intestinal fluid and electrolyte absorption and inhibits anion secretion. It is more potent than native somatostatin and does not exhibit tachyphylaxsis. SMS 201-995 was used to treat two patients with severe diarrhea associated with Crohn’s disease after other treatments had failed. The volume and frequency of ileostomy output in one patient and stool output in the other did not respond to therapy with SMS 201-995. ln fact, diarrhea appeared to increase in both patients while on treatment.http://dx.doi.org/10.1155/1989/525713 |
| spellingShingle | Richard N. Fedorak Richard W. Sherbaniuk Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease Canadian Journal of Gastroenterology |
| title | Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease |
| title_full | Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease |
| title_fullStr | Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease |
| title_full_unstemmed | Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease |
| title_short | Absence of Effect of Somatostatin Analogue (SMS 201-995) in Diarrhea Associated with Inflammatory Bowel Disease |
| title_sort | absence of effect of somatostatin analogue sms 201 995 in diarrhea associated with inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/1989/525713 |
| work_keys_str_mv | AT richardnfedorak absenceofeffectofsomatostatinanaloguesms201995indiarrheaassociatedwithinflammatoryboweldisease AT richardwsherbaniuk absenceofeffectofsomatostatinanaloguesms201995indiarrheaassociatedwithinflammatoryboweldisease |