T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains

T cell epitope content comparison using EpiCC correlates with vaccine efficacy against heterologous porcine reproductive and respiratory syndrome virus type 2 strains

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most ubiquitous RNA viruses affecting pigs and pig farms globally. While vaccines are available, they are not entirely effective, and the introduction of modified live virus vaccines (MLV) has contributed to an increase in the...

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Bibliographic Details
Main Authors: J. Mark Hammer, Andres H. Gutierrez, Lucas Huntimer, Benjamin Gabriel, William D. Martin, Sabine E. Hammer, Tobias Käser, Anne S. De Groot
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Microbiology
Subjects:
porcine reproductive and respiratory syndrome virus (PRRSV)
T cell epitope
vaccine
challenge
immune response
T cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1625309/full
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