The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish
The large superfamily of DExD/H box RNA helicases are involved in various life processes, such as RNA metabolism, transcriptional regulation, translation, tumorigenesis, cell cycle, and viral infection, and RIG-like receptors (RLRs) in the superfamily have been confirmed with crucial roles in viral...
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Elsevier
2024-12-01
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| Series: | Comparative Immunology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950311624000399 |
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| author | Shan Nan Chen Xue Yun Peng Pin Nie |
| author_facet | Shan Nan Chen Xue Yun Peng Pin Nie |
| author_sort | Shan Nan Chen |
| collection | DOAJ |
| description | The large superfamily of DExD/H box RNA helicases are involved in various life processes, such as RNA metabolism, transcriptional regulation, translation, tumorigenesis, cell cycle, and viral infection, and RIG-like receptors (RLRs) in the superfamily have been confirmed with crucial roles in viral infection by recognizing viral RNA. In this review, non-RLR DExD/H box RNA helicases were possibly summarized in relation with their composition and antiviral immune responses in teleost, with at least 52 genes in the helicase subfamily. Compared with mammals, most DExD/H box RNA helicases in teleost are conservatively present, but some are present in a fish-specific gene duplication manner or have been lost in evolution, which may imply the obvious compositional difference in fish. The comparison in innate immune roles of mammalian and teleost DExD/H box RNA helicases indicated that DDX3a, DDX3b, DHX9, DDX41, DDX43 are functional positively in anti-viral/bacterial immunity in fish, while DDX1, DDX3a, DDX5, DDX19, DDX23 negatively in the immunity. In the future, the composition, possible immune recognition, signalling and interaction with other immune pathways, as well as other biological functions are all of significant importance for research, which may contribute to the development of disease prevention and control strategies in aquaculture. |
| format | Article |
| id | doaj-art-5da4e5d7cb9e44018b1a68ae7cdfc71e |
| institution | OA Journals |
| issn | 2950-3116 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
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| series | Comparative Immunology Reports |
| spelling | doaj-art-5da4e5d7cb9e44018b1a68ae7cdfc71e2025-08-20T01:57:55ZengElsevierComparative Immunology Reports2950-31162024-12-01720017210.1016/j.cirep.2024.200172The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fishShan Nan Chen0Xue Yun Peng1Pin Nie2State Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province 430072, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province 430072, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, ChinaState Key Laboratory of Freshwater Ecology and Biotechnology, and Key Laboratory of Aquaculture Disease Control, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei Province 430072, China; School of Marine Science and Engineering, Qingdao Agricultural University, Qingdao, Shandong Province 266109, China; Corresponding author.The large superfamily of DExD/H box RNA helicases are involved in various life processes, such as RNA metabolism, transcriptional regulation, translation, tumorigenesis, cell cycle, and viral infection, and RIG-like receptors (RLRs) in the superfamily have been confirmed with crucial roles in viral infection by recognizing viral RNA. In this review, non-RLR DExD/H box RNA helicases were possibly summarized in relation with their composition and antiviral immune responses in teleost, with at least 52 genes in the helicase subfamily. Compared with mammals, most DExD/H box RNA helicases in teleost are conservatively present, but some are present in a fish-specific gene duplication manner or have been lost in evolution, which may imply the obvious compositional difference in fish. The comparison in innate immune roles of mammalian and teleost DExD/H box RNA helicases indicated that DDX3a, DDX3b, DHX9, DDX41, DDX43 are functional positively in anti-viral/bacterial immunity in fish, while DDX1, DDX3a, DDX5, DDX19, DDX23 negatively in the immunity. In the future, the composition, possible immune recognition, signalling and interaction with other immune pathways, as well as other biological functions are all of significant importance for research, which may contribute to the development of disease prevention and control strategies in aquaculture.http://www.sciencedirect.com/science/article/pii/S2950311624000399DExD/H box RNA helicaseDDXDHXfishRLR |
| spellingShingle | Shan Nan Chen Xue Yun Peng Pin Nie The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish Comparative Immunology Reports DExD/H box RNA helicase DDX DHX fish RLR |
| title | The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish |
| title_full | The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish |
| title_fullStr | The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish |
| title_full_unstemmed | The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish |
| title_short | The composition and unrevealed immune role of non-RLR DExD/H box RNA helicases in fish |
| title_sort | composition and unrevealed immune role of non rlr dexd h box rna helicases in fish |
| topic | DExD/H box RNA helicase DDX DHX fish RLR |
| url | http://www.sciencedirect.com/science/article/pii/S2950311624000399 |
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